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A metabolomics investigation of selected m.3243A>G mutation phenotypes
(North-West University, 2018)
Mitochondrial disease (MD) is a subgroup of inborn errors of metabolism, which can be caused by a mutation in either the nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). One of the most common mtDNA disease causing mutations ...
Application of metabolomics to identify functional metabolic changes associated with Haliotis midae growth
(North-West University, 2018)
The South African abalone, "perlemoen" (as it is called locally) industry is largely based on farming with Haliotis midae, which has been commercially cultured in man-made shore-based systems with great success for the ...
Elucidating the antimicrobial mechanisms of colistin on Mycobacterium tuberculosis using metabolomics
(North-West University, 2018)
In 2014, the WHO declared tuberculosis (TB) an epidemic, as an estimated 9 million people suffered from Mtb infection. Today, millions of mortalities are still reported worldwide as a result of this disease. This growing ...
The altered fatty acylcarnitines, amino acids and organic acids detected in tuberculosis patient urine
(North-West University (South Africa), Potchefstroom Campus, 2018)
Mycobacterium tuberculosis is estimated to infect approximately one-third of the world’s
population, which can lead to an active, symptomatic disease called tuberculosis (TB), or to
asymptomatic states, often referred ...