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Modifying the comet assay for measuring global DNA methylation in a variety of tissue cells
(North-West University, 2010)
It is becoming abundantly clear that DNA methylation plays a crucial role in gene regulation and that aberrant regulation of DNA methylation influences the development of certain diseases such as cancer. Although a wide ...
The assessment of detoxification metabolism in fatty acid oxidation deficiencies
(North-West University, 2010)
The concept of accumulating xenobiotics within the human body as a health risk is well known. However, these compounds can also be endogenous, as in the case of inborn errors of metabolism. Biotransformation of both exogenous ...
An analysis of the effect of transformation on global– and gene–specific DNA methylation in four cultured cell lines
(North-West University, 2010)
DNA methylation plays a role in several biological functions, such as gene expression regulation, and several endogenous and exogenous factors affect these DNA methylation patterns in the cell. One such alteration of a ...
Characterisation of the SULT1A1 polymorphism in a South African Tswana population group
(North-West University, 2010)
This dissertation brings to the fore the “Characterization of the SULT1A1 polymorphism in a
South Africa Tswana population group.” The primary experimental group studied came from
South African homogeneous Tswana individuals ...