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Urinary metabolomics investigation of Ndufs4 knockout mice
(North-West University (South Africa), 2020)
Mitochondrial diseases (MDs) are the most common inborn errors of metabolism, with an estimated prevalence of approximately 1 in 5 000 live births, and are mainly caused by deficiencies of complex I (CI) of the oxidative ...
Metabolomics and biochemical evaluation of skeletal muscle from Ndufs4 knockout mice
(North-West University (South Africa), 2019)
The dysfunction of mitochondrial complex I (CI) impedes the most efficient mechanism feeding electrons into the respiratory chain (RC) — a system that, together with ATP synthase (CV), is responsible for the majority of ...
A metabolomics investigation of selected m.3243A>G mutation phenotypes
(North-West University, 2018)
Mitochondrial disease (MD) is a subgroup of inborn errors of metabolism, which can be caused by a mutation in either the nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). One of the most common mtDNA disease causing mutations ...
Metabolomics of hypertension in South Africans : the SABPA Study
(North-West University (South Africa), 2015)
There has been growing concern in recent years about the alarmingly high prevalence and
severity of hypertension and other cardiovascular diseases in individuals from newly (or
recently) westernised countries such as ...
A metabolomics and biochemical investigation of selected brain regions from Ndufs4 knockout mice
(North-West University (South Africa)North-West University, 2020)
Mitochondria, the organelles found throughout the cytoplasm of most eukaryotic cells, have essential functions which have been implicated in the etiology of numerous metabolic and degenerative diseases. The mitochondrial ...