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Now showing items 11-20 of 34
Ecological risk assessment of amphibians in the Phongolo River floodplain
(North-West University (South Africa), 2021)
The Phongolo River floodplain in South Africa hosts the highest floodplain biodiversity in the
country, while also being highly utilised for commercial and subsistence agriculture. The floodplain
falls within the malaria ...
Investigating the adaptive mitochondrial shuttles and metabolic reprogramming of transporters in complex I (Ndufs4) knockout mice
(North-West University (South Africa), 2022)
Mitochondrial disease is one of the most prevalent inherited paediatric disorders among children, with a prevalence of 1 in 5000 children. Leigh syndrome is the result of a Complex I (CI) deficiency and disrupts the redox ...
Investigating tissue-specificity in a mouse model of Leigh Syndrome using metabolomics
(North-West University (South Africa), 2022)
Mitochondrial disease (MD) is one of the most challenging groups of inborn disorders featuring a
tissue-specific vulnerability, governed by largely unknown mechanisms. The value of
metabolomics in multi-systemic MD ...
Metabolomics and biochemical evaluation of skeletal muscle from Ndufs4 knockout mice
(North-West University (South Africa), 2019)
The dysfunction of mitochondrial complex I (CI) impedes the most efficient mechanism feeding electrons into the respiratory chain (RC) — a system that, together with ATP synthase (CV), is responsible for the majority of ...
Investigating the effect of anaesthesia on the metabolism of zebrafish (D. rerio)
(North-West University (South Africa), 2022)
In recent years, zebrafish (D. rerio) have emerged as valuable research models, being widely
used as models for aquaculture research, but also to model human metabolic diseases. The
ethical guidelines stipulate that ...
The immuno-metabolomics profile of cells presenting differential CCR5 phenotypes
(North-West University (South Africa), 2022)
Background
Chemokines are small molecules that form part of the cytokine family and direct the response of cells to chemical stimuli and thus serve as chemotactic factors. Cysteine-cysteine (C-C) chemokine receptor 5 ...
A metabolomics investigation of selected m.3243A>G mutation phenotypes
(North-West University, 2018)
Mitochondrial disease (MD) is a subgroup of inborn errors of metabolism, which can be caused by a mutation in either the nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). One of the most common mtDNA disease causing mutations ...
Application of metabolomics to identify functional metabolic changes associated with Haliotis midae growth
(North-West University, 2018)
The South African abalone, "perlemoen" (as it is called locally) industry is largely based on farming with Haliotis midae, which has been commercially cultured in man-made shore-based systems with great success for the ...
Elucidating the antimicrobial mechanisms of colistin on Mycobacterium tuberculosis using metabolomics
(North-West University, 2018)
In 2014, the WHO declared tuberculosis (TB) an epidemic, as an estimated 9 million people suffered from Mtb infection. Today, millions of mortalities are still reported worldwide as a result of this disease. This growing ...
Metallothionein involvement in mitochondrial function and disease : a metabolomics investigation
(North-West University, 2011)
One of the many recorded adaptive responses in respiratory chain complex I deficient cells is the over-expression of the small metal binding proteins, metallothioneins (MTs). The antioxidant
properties of MTs putatively ...