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Now showing items 11-20 of 23
Metabolomics and biochemical evaluation of skeletal muscle from Ndufs4 knockout mice
(North-West University (South Africa), 2019)
The dysfunction of mitochondrial complex I (CI) impedes the most efficient mechanism feeding electrons into the respiratory chain (RC) — a system that, together with ATP synthase (CV), is responsible for the majority of ...
A metabolomics investigation of selected m.3243A>G mutation phenotypes
(North-West University, 2018)
Mitochondrial disease (MD) is a subgroup of inborn errors of metabolism, which can be caused by a mutation in either the nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). One of the most common mtDNA disease causing mutations ...
Application of metabolomics to identify functional metabolic changes associated with Haliotis midae growth
(North-West University, 2018)
The South African abalone, "perlemoen" (as it is called locally) industry is largely based on farming with Haliotis midae, which has been commercially cultured in man-made shore-based systems with great success for the ...
Elucidating the antimicrobial mechanisms of colistin on Mycobacterium tuberculosis using metabolomics
(North-West University, 2018)
In 2014, the WHO declared tuberculosis (TB) an epidemic, as an estimated 9 million people suffered from Mtb infection. Today, millions of mortalities are still reported worldwide as a result of this disease. This growing ...
Metallothionein involvement in mitochondrial function and disease : a metabolomics investigation
(North-West University, 2011)
One of the many recorded adaptive responses in respiratory chain complex I deficient cells is the over-expression of the small metal binding proteins, metallothioneins (MTs). The antioxidant
properties of MTs putatively ...
A metabolomics investigation of tuberculous meningitis in infants and children
(North-West University (South Africa), 2016)
This thesis, titled: ‘A metabolomics investigation of Tuberculous Meningitis in infants and children’, deals with tuberculous meningitis (TBM), the most severe complication of tuberculosis (TB) and major pandemic of our ...
Metabolic variation in cultured cells treated with differentially functionalised gold nanoparticles (GNPs)
(North-West University (South Africa), Potchefstroom Campus, 2017)
Gold nanoparticles (GNPs) and differentially functionalised or ligand exchanged GNPs (Lig-GNPs) present promising advantages in a variety of fields. Surface functionalisation of GNPs with ligands is believed to improve the ...
Improving a biosignature for respiratory chain deficiencies in a South African cohort
(North-West University (South Africa) , Potchefstroom Campus, 2016)
Mitochondria are the cell’s main energy producing site, found in the cytoplasm of nearly all eukaryotic cells. These organelles generate cellular energy in the form of adenosine triphosphate (ATP), mostly by means of the ...
Standardisation and implementation of an optimised method for lipid profiling of microbial communities
(North-West University (South Africa), 2016)
Although the importance of phospholipid fatty acid (PLFA) analysis to characterise microbial
communities has been recognised over the years, the vast number of modifications to this traditional
method as well as discrepancies ...
Metabolomics of hypertension in South Africans : the SABPA Study
(North-West University (South Africa), 2015)
There has been growing concern in recent years about the alarmingly high prevalence and
severity of hypertension and other cardiovascular diseases in individuals from newly (or
recently) westernised countries such as ...