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The role of the ESX–3 gene cluster and iron on mycobacterial viability
(North-West University, 2013)
According to the World Health Organization (WHO), M. tuberculosis, the causative agent of TB, accounts for approximately 1.7 million deaths annually. Further contributing causes to the worldwide TB incidence, is the ...
Characterising tuberculosis treatment success and failure using metabolomics
(North-West University, 2013)
Tuberculosis (TB) is one of the deadliest infectious diseases of our time, with 1.4 million
deaths globally, recorded in 2010 (3800 deaths a day) by the World Health Organization
(WHO). Currently, South Africa ranks third ...
A metabolomics approach investigating the functionality of the ESX-1 gene cluster in mycobacteria
(North-West University, 2015)
Tuberculosis (TB) claims the lives of millions of individuals each year, and is
consequently the world’s second-most deadly infectious disease after acquired
immune deficiency syndrome (AIDS), responsible for 1.4 million ...
Application of metabolomics to identify functional metabolic changes associated with Haliotis midae growth
(North-West University, 2018)
The South African abalone, "perlemoen" (as it is called locally) industry is largely based on farming with Haliotis midae, which has been commercially cultured in man-made shore-based systems with great success for the ...
Elucidating the antimicrobial mechanisms of colistin on Mycobacterium tuberculosis using metabolomics
(North-West University, 2018)
In 2014, the WHO declared tuberculosis (TB) an epidemic, as an estimated 9 million people suffered from Mtb infection. Today, millions of mortalities are still reported worldwide as a result of this disease. This growing ...
The altered fatty acylcarnitines, amino acids and organic acids detected in tuberculosis patient urine
(North-West University (South Africa), Potchefstroom Campus, 2018)
Mycobacterium tuberculosis is estimated to infect approximately one-third of the world’s
population, which can lead to an active, symptomatic disease called tuberculosis (TB), or to
asymptomatic states, often referred ...
The metabolic profile of clinical and immunogenetic factors linked to HIV progression
(North-West University (South Africa)North-West University, 2020)
HIV disease progression is generally defined by the time it takes an individual to progress from primary HIV infection to the acquired immunodeficiency syndrome (AIDS). CD4 T-cell count and plasma viral load are validated ...