Now showing items 1-2 of 2
Urinary metabolomics investigation of Ndufs4 knockout mice
(North-West University (South Africa), 2020)
Mitochondrial diseases (MDs) are the most common inborn errors of metabolism, with an estimated prevalence of approximately 1 in 5 000 live births, and are mainly caused by deficiencies of complex I (CI) of the oxidative ...
Investigating tissue-specificity in a mouse model of Leigh Syndrome using metabolomics
(North-West University (South Africa), 2022)
Mitochondrial disease (MD) is one of the most challenging groups of inborn disorders featuring a
tissue-specific vulnerability, governed by largely unknown mechanisms. The value of
metabolomics in multi-systemic MD ...