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Urinary metabolomics investigation of Ndufs4 knockout mice
(North-West University (South Africa), 2020)
Mitochondrial diseases (MDs) are the most common inborn errors of metabolism, with an estimated prevalence of approximately 1 in 5 000 live births, and are mainly caused by deficiencies of complex I (CI) of the oxidative ...
Investigating the adaptive mitochondrial shuttles and metabolic reprogramming of transporters in complex I (Ndufs4) knockout mice
(North-West University (South Africa), 2022)
Mitochondrial disease is one of the most prevalent inherited paediatric disorders among children, with a prevalence of 1 in 5000 children. Leigh syndrome is the result of a Complex I (CI) deficiency and disrupts the redox ...
Metabolomics and biochemical evaluation of skeletal muscle from Ndufs4 knockout mice
(North-West University (South Africa), 2019)
The dysfunction of mitochondrial complex I (CI) impedes the most efficient mechanism feeding electrons into the respiratory chain (RC) — a system that, together with ATP synthase (CV), is responsible for the majority of ...
Investigating the effect of anaesthesia on the metabolism of zebrafish (D. rerio)
(North-West University (South Africa), 2022)
In recent years, zebrafish (D. rerio) have emerged as valuable research models, being widely
used as models for aquaculture research, but also to model human metabolic diseases. The
ethical guidelines stipulate that ...
A metabolomics investigation of selected m.3243A>G mutation phenotypes
(North-West University, 2018)
Mitochondrial disease (MD) is a subgroup of inborn errors of metabolism, which can be caused by a mutation in either the nuclear DNA (nDNA) or mitochondrial DNA (mtDNA). One of the most common mtDNA disease causing mutations ...
Application of metabolomics to identify functional metabolic changes associated with Haliotis midae growth
(North-West University, 2018)
The South African abalone, "perlemoen" (as it is called locally) industry is largely based on farming with Haliotis midae, which has been commercially cultured in man-made shore-based systems with great success for the ...
Metabolomics of hypertension in South Africans : the SABPA Study
(North-West University (South Africa), 2015)
There has been growing concern in recent years about the alarmingly high prevalence and
severity of hypertension and other cardiovascular diseases in individuals from newly (or
recently) westernised countries such as ...
The altered fatty acylcarnitines, amino acids and organic acids detected in tuberculosis patient urine
(North-West University (South Africa), Potchefstroom Campus, 2018)
Mycobacterium tuberculosis is estimated to infect approximately one-third of the world’s
population, which can lead to an active, symptomatic disease called tuberculosis (TB), or to
asymptomatic states, often referred ...
A metabolomics and biochemical investigation of selected brain regions from Ndufs4 knockout mice
(North-West University (South Africa)North-West University, 2020)
Mitochondria, the organelles found throughout the cytoplasm of most eukaryotic cells, have essential functions which have been implicated in the etiology of numerous metabolic and degenerative diseases. The mitochondrial ...