Search
Now showing items 1-4 of 4
CoenzymeQ10-associated gene mutations in South African patients with respiratory chain deficiencies
(North-West University, 2015)
CoenzymeQ10 (CoQ10) functions as an electron carrier in mitochondria transporting electrons from CI and CII to CIII in the respiratory chain (RC) for normal cellular energy (ATP) production. Mutations in genes of a complicated ...
Investigation and characterisation of the genetic variation in the coding region of the glycine N-acyltransferase gene
(North-West University, 2015)
Thorough investigation of the glycine conjugation pathway has been neglected over the last 30 years. Environmental factors, nutrition, and the chronic use of medications are increasing the exposure of humans to benzoate ...
Quantification of coenzymeQ10 in South African pediatric patients with electron transport chain deficiencies
(North-West University (South Africa), Potchefstroom Campus, 2015)
CoenzymeQ10 (CoQ10) is an important component of the mitochondrial electron transport chain
(ETC). Co010 deficiency mainly affects children, and patients present with heterogeneous
clinical phenotypes. Patients frequently ...
Metabolomics of hypertension in South Africans : the SABPA Study
(North-West University (South Africa), 2015)
There has been growing concern in recent years about the alarmingly high prevalence and
severity of hypertension and other cardiovascular diseases in individuals from newly (or
recently) westernised countries such as ...