Now showing items 1-4 of 4
Phase 2 biotransformation : the targeted profiling of glycine amino acid conjugation
(North-West University (South Africa), Potchefstroom Campus, 2015)
The hepatic biotransformation system plays an important role in drug metabolism and toxicity and has been studied quite extensively. The importance of the very first biotransformation reaction discovered, namely phase 2 ...
Transcriptomic and functional characterisation of marginal and clinically severe 3-methylcrotonyl-CoA carboxylase deficiency
(North-West University (South Africa), 2015)
Urinary 3-hydroxyisovaleric acid and 3-methylcrotonylglycine are usually indicative of the possibility of 3-methylcrotonyl-CoA carboxylase (MCC) deficiency. In this study a South African family which presented with these ...
Investigation and characterisation of the genetic variation in the coding region of the glycine N-acyltransferase gene
(North-West University, 2015)
Thorough investigation of the glycine conjugation pathway has been neglected over the last 30 years. Environmental factors, nutrition, and the chronic use of medications are increasing the exposure of humans to benzoate ...
Cloning and evaluation of expression of the open reading frames of a South African G9P rotavirus strain encoding rotavirus structural proteins VP2 and VP6 in bacteria and yeast
Rotavirus infection causes severe gastroenteritis, affecting all children under the age of five regardless of hygiene or water quality. The currently licensed vaccines succeeded in reducing diarrhoea worldwide, but they ...