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The role of the ESX–3 gene cluster and iron on mycobacterial viability
(North-West University, 2013)
According to the World Health Organization (WHO), M. tuberculosis, the causative agent of TB, accounts for approximately 1.7 million deaths annually. Further contributing causes to the worldwide TB incidence, is the ...
Characterising tuberculosis treatment success and failure using metabolomics
(North-West University, 2013)
Tuberculosis (TB) is one of the deadliest infectious diseases of our time, with 1.4 million
deaths globally, recorded in 2010 (3800 deaths a day) by the World Health Organization
(WHO). Currently, South Africa ranks third ...
A metabolomics approach investigating the functionality of the ESX-1 gene cluster in mycobacteria
(North-West University, 2015)
Tuberculosis (TB) claims the lives of millions of individuals each year, and is
consequently the world’s second-most deadly infectious disease after acquired
immune deficiency syndrome (AIDS), responsible for 1.4 million ...
Elucidating the antimicrobial mechanisms of colistin on Mycobacterium tuberculosis using metabolomics
(North-West University, 2018)
In 2014, the WHO declared tuberculosis (TB) an epidemic, as an estimated 9 million people suffered from Mtb infection. Today, millions of mortalities are still reported worldwide as a result of this disease. This growing ...
The altered fatty acylcarnitines, amino acids and organic acids detected in tuberculosis patient urine
(North-West University (South Africa), Potchefstroom Campus, 2018)
Mycobacterium tuberculosis is estimated to infect approximately one-third of the world’s
population, which can lead to an active, symptomatic disease called tuberculosis (TB), or to
asymptomatic states, often referred ...
The effect of sex and HIV on the TB-induced altered sputum metabolome
(North-West University (South Africa), 2023)
Various studies have identified TB-induced metabolome variations. However, in most of these studies, the unaccounted-for variation between individual patients is noteworthy. To investigate one potential cause of this ...
The altered urine metabolome induced by DOTS therapy in pulmonary tuberculosis patients
(North-West University (South Africa), 2023)
Metabolomics holds great promise for studying complex diseases like tuberculosis (TB), where treatment outcomes are influenced by a combination of biological, environmental, and social factors. This study aimed to gain a ...