Now showing items 1-2 of 2
Urinary metabolomics investigation of Ndufs4 knockout mice
(North-West University (South Africa), 2020)
Mitochondrial diseases (MDs) are the most common inborn errors of metabolism, with an estimated prevalence of approximately 1 in 5 000 live births, and are mainly caused by deficiencies of complex I (CI) of the oxidative ...
Metabolomics and biochemical evaluation of skeletal muscle from Ndufs4 knockout mice
(North-West University (South Africa), 2019)
The dysfunction of mitochondrial complex I (CI) impedes the most efficient mechanism feeding electrons into the respiratory chain (RC) — a system that, together with ATP synthase (CV), is responsible for the majority of ...