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Urinary metabolomics investigation of Ndufs4 knockout mice
(North-West University (South Africa), 2020)
Mitochondrial diseases (MDs) are the most common inborn errors of metabolism, with an estimated prevalence of approximately 1 in 5 000 live births, and are mainly caused by deficiencies of complex I (CI) of the oxidative ...
The metabolic profile of clinical and immunogenetic factors linked to HIV progression
(North-West University (South Africa)North-West University, 2020)
HIV disease progression is generally defined by the time it takes an individual to progress from primary HIV infection to the acquired immunodeficiency syndrome (AIDS). CD4 T-cell count and plasma viral load are validated ...
A metabolomics and biochemical investigation of selected brain regions from Ndufs4 knockout mice
(North-West University (South Africa)North-West University, 2020)
Mitochondria, the organelles found throughout the cytoplasm of most eukaryotic cells, have essential functions which have been implicated in the etiology of numerous metabolic and degenerative diseases. The mitochondrial ...