Browsing Natural and Agricultural Sciences by Subject "Mitochondria"
Now showing items 1-5 of 5
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Analysis of metallothionein gene expression in oxidative stress related disorders
(North-West University, 2004)Increased reactive oxygen species (ROS) have been reported to be at the centre of various diseases. Although several reports have implicated elevated levels of ROS in the pathogenesis of diabetes mellitus, the early ... -
An evaluation of mitochondrial DNA replication and transcription as well as the transcription of selected nuclear genes in in vitro models for OXPHOS deficiencies
(North-West University, 2010)Deficiencies of the oxidative phosphorylation system (OXPHOS) that consists of five enzyme complexes (I-IV) lead to a diversity of cellular consequences. This includes altered Ca2+ homeostasis, reduced ATP production and ... -
Investigating the adaptive mitochondrial shuttles and metabolic reprogramming of transporters in complex I (Ndufs4) knockout mice
(North-West University (South Africa), 2022)Mitochondrial disease is one of the most prevalent inherited paediatric disorders among children, with a prevalence of 1 in 5000 children. Leigh syndrome is the result of a Complex I (CI) deficiency and disrupts the redox ... -
Metallothionein involvement in mitochondrial function and disease : a metabolomics investigation
(North-West University, 2011)One of the many recorded adaptive responses in respiratory chain complex I deficient cells is the over-expression of the small metal binding proteins, metallothioneins (MTs). The antioxidant properties of MTs putatively ... -
Sub-cellular metabolomics investigation of mitochondrial CI deficiency in cytosol & mitochondria of Ndufs4 mice
(North-West University (South Africa), 2022)Mitochondrial Complex I (CI) is regarded as the foremost entry point for electrons that fuel oxidative phosphorylation. CI deficiency (CID) is the most common mitochondrial disease (MD) in humans and Leigh syndrome (LS), ...