Now showing items 1-2 of 2
The inhibition of phosphodiesterase type 5 as a novel target for antidepressant action
(North-West University, 2009)
Major depression is one of the most debilitating diseases of our time, while current antidepressant treatments remain deficient in several ways. The nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) / cGMP-dependent ...
The role of alpha-2A-adrenergic receptor antagonism in therapeutic efficacy and onset of action of antidepressant drugs in a rat model of depression
(North-West University, 2006)
While delayed onset of antidepressant action remains a shortcoming of current antidepressants, preliminary clinical data with newer antidepressants, including mirtazapine, show promise for a hastened onset. Several potential ...