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Now showing items 31-34 of 34
The synthesis and evaluation of caffeine analogues as inhibitors of monoamine oxidase B and antagonists of the adenosine A₂A receptor
(North-West University, 2008)
The adenosine A2A receptor has emerged as an attractive target for the treatment of Parkinson's disease (PD). Evidence suggests that antagonists of the A2A receptor (A2A antagonists) partially alleviate the symptoms of PD, ...
The synthesis and evaluation of N-methyl-2-phenylmaleimide analogues as inhibitors of MAO-B
(North-West University, 2008)
We have recently demonstrated that 1-methyl-3-phenylpyrrole analogues are moderately potent competitive inhibitors of the enzyme monoamine oxidase B (MAO-B). The most potent analogue was 1-methyl-(4-trifluoromethylphenyl) ...
Evaluation of nitrocatechol bearing cyclic chalcones and related analogues as dual monoamine oxidase and catechol-O-methyltransferase inhibitors
(North-West University (South-Africa), 2020)
Parkinson’s disease (PD) is one of the leading causes of disability in the world. A better understanding of the aetiology of this disorder will lead to better medications, and would improve the quality of life for millions ...
In vitro and in silico antimicrobial evaluation of N- methyl-2-phenylmaleimides
(North-West University (South-Africa), 2023)
Due to COVID-19, many other pandemics have been overlooked in the past few years.
Antimicrobial resistance (AMR) is a pandemic that have killed more people than Human
Immunodeficiency Virus (HIV) and malaria in 2019 and ...