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Now showing items 31-36 of 36
Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats
(North-West University, 2007)
Schizophrenia affects approximately 1% of the population. Despite marked improvement in drug treatment, 20% of patients remain treatment resistant while motor side effects hamper compliance and outcome. A better understanding ...
Depressive symptoms and cardiometabolic health in urban black Africans : the SABPA study
(2014)
Motivation - Depression is a mental disorder that has been associated with cardiovascular morbidity and mortality in the Western world. Cardio-metabolic mechanisms have been implicated as possible intermediating factors ...
Ethological foundations of measuring obsessive-compulsive phenotypes in the deer mouse: a methodological perspective
(North-West University (South-Africa), 2020)
Pre-clinical models which leverage the study of animal behavior are invaluable tools to advance our understanding of a variety of psychological constructs. Such ethological investigations allow us to gain insight into ...
Evaluating the antidepressant-like properties of Sceletium tortuosum, alone and as adjunctive treatment
(North-West University (South-Africa), 2020)
BACKGROUND: Millions of people worldwide suffer from major depressive disorder (MDD) which can cause physical and emotional suffering for patients and their loved-ones. Unfortunately current treatment fails in approximately ...
Nest building and marble burying: Dopaminergic phenotyping of the deer mouse model of obsessive-compulsive disorder (OCD)
(North-West University (South-Africa), 2020)
Obsessive-compulsive disorder (OCD1) is a chronic, debilitating psychiatric condition that affects 3% of the global population and is characterized by obsessions, and compulsions. 40 – 60% of patients remain treatment-resistant ...
An exploration into the bio-behavioural characteristics of the Ndufs4 (knockout) mice : a novel preclinical perspective on psychiatric conditions
(North-West University (South-Africa), 2023)
The brain and its associated disorders as a field of study are extremely complex, even more so when research strives to create models that mimic human psychiatric conditions. Given that psychiatric illnesses are associated ...