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Now showing items 21-30 of 31
Development and evaluation of a self-emulsifying drug delivery system for artemether and lumefantrine
(North-West University (South-Africa), 2019)
Malaria is a grave concern globally, however, in sub-Saharan Africa it remains an even more severe problem due to the fact that more than 90% of all malaria cases caused by Plasmodium falciparum reside in this region. The ...
Enhancing the solubility and in vitro permeability of pyrimethamine
(North-West University (South-Africa), 2021)
ABSTRACT
Malaria poses a substantial health problem, with nearly half of the world’s population susceptible to it. Malaria causes an estimated one million deaths per year. People who fall prey to malaria are also burdened ...
Development of lipid matrix tablets containing a double fixed dose combination of artemisone and lumefantrine
(North-West University, 2018)
Malaria is one of the most important parasitic diseases as well as one of the most life-threatening diseases known to man. This vector-borne disease caused by Plasmodium spp., is responsible for over 438 000 deaths globally, ...
Radio-labelling as a tool to investigate the absorption and bio-distribution of selected antimalarial drugs
(2014)
Previous studies have shown that the formulation of an active pharmaceutical ingredient (API) entrapped in the Pheroid® (Pheroid for simplification) delivery system enhances absorption of the API, suppresses its metabolism, ...
The discriminatory ability of analytical quality control test methods : a comparison of test results from different international monographs of quinine sulfate tablets
(2013)
Malaria is a parasitic disease claiming one million lives worldwide annually. Unfortunately, malaria-endemic countries in need of good quality medicines are also overwhelmed with counterfeit or substandard medicine. This ...
Synthesis and in vitro antimalarial activity of esters with truncated artemisinin scaffold
(North-West University (South Africa) , Potchefstroom Campus, 2017)
Malaria is an infectious disease caused by Plasmodium parasites, with P. falciparum, responsible for most cases of morbidity and mortality. In 2014, malaria killed 438 000 people, with most deaths occurring in sub-Saharan ...
Synthesis, cytotoxicity and antiplasmodial activity of novel ferrocenyl-artemisinin hybrids
(North-West University (South-Africa). Potchefstroom Campus, 2019)
Malaria is caused by a parasite of the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most dangerous. This disease caused 435 thousand deaths in 2017. It is estimated that 266 thousand ...
Synthesis and biological evaluation of novel 11-azaartemisinin derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2017)
Malaria is a devastating mosquito-borne disease caused by several species of Plasmodium protozoa, of which the most important is Plasmodium falciparum (Pf). Globally, the disease caused approximately 438 000 deaths in 2014; ...
Malaria prevalence, management trends and the knock down resistance profile of Anopheles gambiae in Mbakong, Cameroon
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Malaria remains a scourge in the world. Recent efforts to combat malaria combine chemotherapy and vector control. Cameroon in 2004 adopted WHO 2001 recommendations and changed her malaria treatment guidelines from monotherapy ...
The preparation of artemisinin-cholesterol conjugates as potential new drugs for treatment of intractable forms of tuberculosis and malaria
(North-West University (South Africa) , Potchefstroom Campus, 2016)
Malaria and tuberculosis (TB) are two lethal infectious diseases that continue to plague mankind and claim many lives. These diseases are more prevalent in developing countries especially in Africa and Asia. Malaria alone ...