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Now showing items 21-26 of 26
Synthesis and in vitro antimalarial activity of esters with truncated artemisinin scaffold
(North-West University (South Africa) , Potchefstroom Campus, 2017)
Malaria is an infectious disease caused by Plasmodium parasites, with P. falciparum, responsible for most cases of morbidity and mortality. In 2014, malaria killed 438 000 people, with most deaths occurring in sub-Saharan ...
Synthesis, cytotoxicity and antiplasmodial activity of novel ferrocenyl-artemisinin hybrids
(North-West University (South-Africa). Potchefstroom Campus, 2019)
Malaria is caused by a parasite of the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most dangerous. This disease caused 435 thousand deaths in 2017. It is estimated that 266 thousand ...
Synthesis and biological evaluation of novel 11-azaartemisinin derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2017)
Malaria is a devastating mosquito-borne disease caused by several species of Plasmodium protozoa, of which the most important is Plasmodium falciparum (Pf). Globally, the disease caused approximately 438 000 deaths in 2014; ...
Malaria prevalence, management trends and the knock down resistance profile of Anopheles gambiae in Mbakong, Cameroon
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Malaria remains a scourge in the world. Recent efforts to combat malaria combine chemotherapy and vector control. Cameroon in 2004 adopted WHO 2001 recommendations and changed her malaria treatment guidelines from monotherapy ...
The preparation of artemisinin-cholesterol conjugates as potential new drugs for treatment of intractable forms of tuberculosis and malaria
(North-West University (South Africa) , Potchefstroom Campus, 2016)
Malaria and tuberculosis (TB) are two lethal infectious diseases that continue to plague mankind and claim many lives. These diseases are more prevalent in developing countries especially in Africa and Asia. Malaria alone ...
Development and evaluation of a solid oral dosage form for an artesunate and mefloquine drug combination
(2014)
Malaria affects about forty percent of the world’s population. Annually more than 1.5 million fatalities due to malaria occur and parasite resistance to existing antimalarial drugs such as mefloquine has already reached ...