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Now showing items 21-30 of 36
A metagenomic microbiome investigation in the deer mouse : a translational approach to obsessive-compulsive disorder
(North-West University (South-Africa), 2019)
Obsessive-compulsive disorder (OCD)1 is characterized by persistent, intrusive and often anxiety-provoking thoughts, i.e. obsessions and/or ritualistic behaviors (compulsions) that are expressed in an attempt to reduce the ...
Persistent behavioural phenotypes in the deer mouse and its response to serotonergic and dopaminergic intervention
(North-West University (South-Africa), 2019)
Obsessive compulsive disorder (OCD)1 is a debilitating psychiatric disorder that presents with intrusive thoughts (obsessions) and repetitive ritualistic behaviour (compulsions) as main symptoms. Selective reuptake inhibitors ...
Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
(North-West University (South-Africa), 2019)
The highly active antiretroviral therapy, efavirenz (EFV), has been noted to occur as a constituent of a potent new designer drug cocktail called “Nyaope” or “Whoonga”, which is reported to have mind-altering and addictive-like ...
Investigating the role of AMPAkines in an animal model of post-traumatic stress disorder (PTSD)
(North-West University, 2008)
Post-traumatic stress disorder (PTSD) is a severe anxiety disorder affecting cognitive function. 1 in 4 individuals exposed to a life-threatening event may develop PTSD, which is characterised by symptoms of hyperarousal, ...
Investigating the role of the NO-cGMP pathway in an animal model of posttraumatic stress disorder (PTSD)
(North-West University, 2004)
Posttraumatic stress disorder (PTSD) is a severe anxiety disorder characterised by
hypothalamic-pituitary-adrenal (HPA)-axis abnormalities, hyperarousal, anxiety,
flashbacks of trauma memories and avoidance. Increasing ...
A bio-behavioural investigation into the role of the cholinergic system in stress
(North-West University, 2006)
Posttraumatic stress disorder (PTSD) is an anxiety disorder that may follow exposure to
severe emotional trauma and presents with various symptoms of anxiety, hyperarousal and cognitive anomalies. Interestingly, only ...
The role of monoamines in post traumatic stress disorder (PTSD) using a time dependent sensitization animal model
(North-West University, 2004)
Posttraumatic stress disorder (PTSD) is an anxiety disorder that may result from an exposure to a severely traumatic life-event. It is characterised by a delayed onset of psychological and physical symptoms including ...
Stereotypical behaviour in the deer mouse (Peromyscus Maniculatus bairdii) : a pharmacological investigation of the frontal–cortico–striatal serotonergic system
(North-West University, 2011)
Obsessive–compulsive disorder (OCD) is a psychiatric condition that is characterized by two main symptom cohorts, namely recurrent inappropriate thoughts (obsessions) and seemingly purposeless repetitive motor actions ...
Studies on N-acetyl cysteine as a therapeutic intervention in methamphetamine-associated bio-behavioural changes in an immune-inflammatory model
(2015)
Purpose: Schizophrenia is a severe illness, affecting 0.5-1% of the world population. The clinical manifestation of schizophrenia is characterized by three distinct categories of symptoms, namely positive, negative and ...
Behavioural, neurochemical, inflammatory and mitichondrial markers following social isolation rearing in rats before and after selected deug intervention
(North-West University, 2012)
Purpose: Schizophrenia is a progressive degenerative illness that has been causally linked to mitochondrial dysfunction, oxidative stress and a pro-inflammatory state. Social isolation rearing (SIR) in rats models the ...