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Now showing items 11-20 of 31
Synthesis and in vitro antimalarial activity of novel chalcone derivatives
(2014)
Malaria is endemic in 106 countries worldwide. This disease is caused by a parasite from the genus Plasmodium. Of the five species that infect humans, Plasmodium falciparum is the most virulent, with over three billion ...
Formulation, characterisation and in vivo efficacy of dapsone and proguanil in trimethylated chitosan microparticles
(2014)
Malaria is an infectious disease caused by various forms of the Plasmodium parasite. It is responsible for thousands of deaths yearly with 90 % of those deaths being in sub-Saharan Africa, thus making it a disease of global ...
Efficacy enhancement of the antimalarial drugs, mefloquine and artesunate, with PheroidTM technology
(North-West University, 2010)
Malaria is currently one of the most imperative parasitic diseases in developing countries. Artesunate has a short half-life, low aqueous solubility and resultant poor and erratic absorption upon oral administration, which ...
International pharmacopoeia monographs : antimalarial dosage forms
(North-West University, 2010)
Malaria is a disease affecting millions of people in 109 malarious countries and
territories, causing approximately one million deaths annually. In 2004 one of the
parasites causing human malaria, Plasmodium falciparum, ...
Preparation, stability and in vitro evaluation of liposomes containing chloroquine
(North-West University, 2010)
Malaria is currently a huge treat worldwide, as far as infections are concerned, and is
responsible for thousands of deaths per annum. The dilemma associated with the development of anti–malarial drug resistance over the ...
Preparation, stability and in vitro evaluation of liposomes containing amodiaquine
(North-West University, 2010)
Malaria is a curable disease that claims nearly one million lives each year. Problems with the treatment of malaria arise as resistance spreads and new treatment options are becoming less effective. The need for new ...
Novel artemisinin derivatives with PheroidTM technology for malaria treatment
(North-West University, 2009)
Artemisinins are known for their low aqueous solubility and resultant poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate, to low bibavailability. Enzymatic ...
The effect of Pheroid™ technology on the bioavailability of quinoline–based anti–malarial compounds in primates
(North-West University, 2012)
Resistance against anti-malarial drugs remains one of the greatest obstacles to the effective control of malaria. The current first-line treatment regimen for uncomplicated P.falciparum malaria is based on artemisinin ...
Exploration of benzofuran as scaffold for the design of potent and selective PfGSK-3 inhibitors
(North-West University (South-Africa), 2021)
Control and prevention of malaria in endemic regions rely heavily on vector management (insecticide-treated bed nets and indoor residual spraying) and the limited number of effective antimalarial drugs. Unfortunately, the ...
Development of lipid matrix tablets containing a double-fixed dose combination of artemether and lumefantrine
(North-West University (South-Africa), 2019)
Malaria remains one of the most serious vector-borne and prominent life-threatening diseases in sub-Saharan Africa. Africa has the heaviest malarial disease burden in the world, accounting for 91% of the estimated 445 000 ...