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Now showing items 11-20 of 36
The inhibition of phosphodiesterase type 5 as a novel target for antidepressant action
(North-West University, 2009)
Major depression is one of the most debilitating diseases of our time, while current antidepressant treatments remain deficient in several ways. The nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) / cGMP-dependent ...
The modulating effect of myo-inositol and prototypical antidepressants on markers of cellular resilience in cultured human neuroblastoma cells
(North-West University, 2006)
Although several antidepressants are available for the treatment of depression, certain limitations are common, including drug resistance and significant side effects. Recently, several studies indicated the possibility ...
The role of the NO-cGMP pathway as a putative target in antidepressant action
(North-West University, 2004)
Depressive disorders are among the most frequent psychiatric diseases in the Western world with prevalence between 9% and 18%. Poor compliance and inappropriate antidepressant discontinuation invokes long-term morbidity, ...
Structure-activity relationship of methylene blue and its analogues as lead compounds for novel antidepressant development
(North-West University, 2010)
Antidepressants target serotonergic and/or catecholaminergic responses in an attempt at treating depression yet are at best 65% effective. New antidepressants, as well as new targets for antidepressant action, are thus ...
Regional neurochemical characterization of the flinders sensitive line rat with regard to gaba and cholinergic signalling pathways
(North-West University, 2008)
Despite their acknowledged efficacy, currently available antidepressants still demonstrate undesirable side effects, shortfalls in effectiveness and a delayed onset of action. All these agents act via monoaminergic mechanisms, ...
The long-term effects of methamphetamine on depressive-like behaviour and neuroplasticity in stress-sensitive rats
(2014)
Methamphetamine (METH) abuse has become a fast growing drug problem that has developed into a global epidemic. In fact, METH is one of the most commonly abused substances with an estimated 35 million abusers worldwide and ...
Bio-behavioural effects of novel glutamate active compounds in a rodent model of depression
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Major depressive disorder is a universal neuropsychiatric disorder affecting individuals on a global scale. It causes major disability independent of age, gender, ethnicity, sociological or economic status with an increasing ...
The modulatory effects of sildenafil and the cholinergic system on antidepressant action in a rat model of depression
(North-West University, 2006)
Sildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, is registered for the treatment of male erectile dysfunction (Viagra®) and pulmonary hypertension (Revatio®) in the United States. PDE5 is found in the ...
The modulating effect of sildenafil on cell viability and on the function of selected pharmacological receptors in cell cultures
(North-West University, 2004)
Since sildenafil's (Viagra®), a phospodiesterase type 5 (PDE5) inhibitor, approval for the treatment of male erectile dysfunction (MED) in the United States early 1998, 274 adverse event reports were filed by the Food and ...
A behavioural investigation into the potential antidepressant-like properties of trimetazidine in an animal model of depression
(North-West University (South Africa), 2021)
Major depressive disorder (MDD) is a neuropsychological disorder that affects up to 20 % of adolescents. Current first-line treatment strategies are, at best, effective in only 65 % of depressed patients, and are limited ...