Search
Now showing items 11-20 of 29
Design and synthesis of heterocyclic compounds for neuroprotective enzyme interactions
(North-West University, 2010)
Neurodegenerative diseases are thought to be multifactorial in nature and therefore
current research focus has shifted from a ‘one-drug-one-target’ approach to that of multitarget directed ligands (MTDLs). These ligands ...
Inhibition of monoamine oxidase B by substituted coumarin derivatives
(North-West University, 2008)
Interest in the selective inhibition of monoamine oxidase B (MAO-B) has increased in the last years due to their therapeutic potential in age related neurodegenerative diseases such as Alzheimer's disease and Parkinson's ...
Selective enzyme inhibition in the prevention of neuronal apoptosis : a molecular modelling study
(North-West University, 2009)
Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD) are neurodegenerative diseases which may be caused by neuronal apoptosis and there are currently no treatments to delay the progression of ...
The preparation and evaluation of xanthinyl analogues as inhibitors of monoamine oxidase B
(North-West University, 2006)
Monoamine oxidase B (MAO-B) is a drug target for the treatment of neurodegenerative diseases such as Parkinson's disease. For example, the mechanism-based inactivator of MAO-B,
(R)-deprenyl, is frequently used in combination ...
The synthesis and evaluation of 8–benzyloxycaffeine analogues as inhibitors of monoamine oxidase B
(North-West University, 2009)
Monoamine oxidase, especially monoamine oxidase 8 (MAO-B), plays a major role in the therapy of Parkinson's disease (PO). MAO-8 is the main enzyme responsible for the catabolism of dopamine in the substantia nigra of the ...
Polycyclic aminoguanidines : novel entities for neuroprotection
(North-West University, 2005)
Neurodegenerative diseases such as Parkinson's and Alzheimer's disease as
well as acute disorders for example cerebral ischemia are amongst others associated with an excess production of nitric oxide (NO) in the central ...
Structure-activity relationship of methylene blue and its analogues as lead compounds for novel antidepressant development
(North-West University, 2010)
Antidepressants target serotonergic and/or catecholaminergic responses in an attempt at treating depression yet are at best 65% effective. New antidepressants, as well as new targets for antidepressant action, are thus ...
Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration
(North-West University, 2012)
Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events ...
Neuroprotective effects of amantadine–flavonoid conjugates
(North-West University, 2011)
Neurodegenerative disorders like Parkinson’s and Alzheimer’s disease affect millions of people around the world. Oxidative stress has been implicated in the pathogenesis of a number of neurodegenerative disorders, cancer ...
Rational approaches towards the design of (E)-8-(3-Chlorostyryl)-caffeine derivatives as novel reversible inhibitors of monoamine oxidase B
(North-West University, 2005)
Reversible and selective inhibitors of monoamine oxidase B (MAO-B) are under
investigation for the treatment and prevention of Parkinson's disease (PD) and
Alzheimer's disease. The mechanism-based inactivator of MAO-B, ...