Search
Now showing items 1-10 of 31
Development and evaluation of an oral fixed–dose triple combination dosage form for artesunate, dapsone and proguanil
(North-West University, 2011)
Malaria is a life–threatening disease caused by Plasmodium spp and causes over one million deaths annually. The complex life cycle of the malaria parasite offers several points of attack for the antimalarial drugs. The ...
Dihydroartemisinin esters as prodrugs against resistant P. falciparum strains
(North-West University, 2011)
Malaria is caused by the Plasmodium sp. parasite that infects the red blood cells. Of the four types of malaria, the most serious type is transmitted by Plasmodium falciparum species. It can be life threatening. The other ...
In vitro antimalarial efficacy enhancement of selected antibiotics with PheroidTM technology
(North-West University, 2010)
The Plasmodium falciparum parasite, carried by Anopheles mosquitoes, is currently a global problem due to the rising incidence of resistance of the parasite to available antimalaria drugs. Resistance and difficult treatment ...
Evaluation and validation of methods to determine parasitemia in malaria cell cultures
(North-West University, 2008)
The success in the treatment of malaria is dependent on the prompt and accurate diagnosis of malaria and effectiveness of the drug regime used. The emerging of resistance to most antimalarial drug makes the treatment of ...
Triazole-linked 1,4-naphthoquinone derivatives : synthesis and antiplasmodial activity
(North-West University (South-Africa). Potchefstroom Campus, 2019)
Malaria is a protozoan disease transmitted to humans through female Anopheles mosquitoes.
The malaria parasite thrives in tropical areas, thus people there are at higher risk, especially in
third-world countries like ...
Synthesis and biological evaluation of novel artemisone derivatives
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Despite intensive international efforts to eradicate malaria, the disease, continues to inflict an enormous toll on human lives, especially in Africa. An estimated 198 million malaria cases and 584, 000 deaths were reported ...
Preclinical evaluation of the possible enhancement of the efficacy of anti-malarial drugs by pheroid technology
(North-West University, 2007)
Malaria is currently one of the most imperative parasitic diseases of the developing world. Current effective treatment options are limited because of increasing drug resistance, treatment cost effectiveness and treatment ...
Artemisinin–quinoline hybrids : design, synthesis and antimalarial activity
(North-West University, 2013)
Introduction - Malaria is a major global health problem, with more than 500 million reported cases and at least 1 million deaths each year. The main problem with malaria control is the emerging drug resistance. Plasmodium ...
The effect of Pheroid® technology on the bioavailability of artemisone in primates
(2014)
Malaria is one the world’s most devastating diseases. Several classes of drugs are used to treat malaria. Artemisinin combination therapy is the first line treatment of uncomplicated malaria. The artemisinin derivative, ...
Synthesis and antimalarial activity screening of artemisinin-acridine hybrids
(2013)
Malaria endemic areas not only pose a public health threat, but affects 3.3 billion people
worldwide. In 2011, estimated malaria related deaths amounted to 660 000 out of 219 million reported cases, with 81% of these and ...