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The modulating effect of myo-inositol and other antidepressants on the mRNA levels and protein expression of selected subcellular enzymes
(North-West University, 2005)
Myo-lnositol (mIns), a natural component of the human diet and essential precursor of
several signalling pathways, including that of G protein-coupled receptors, has also been
shown to be effective in the treatment of ...
Investigating a pharmacological agent against tobacco smoke addiction using the rat as animal model
(North-West University, 2004)
It is widely accepted that the majority of people who smoke tobacco do so to experience the psychopharmacological effects of the nicotine present in the smoke. Drugs of abuse activate the brain area called the nucleus ...
Characterisation of the ?2A-adrenoceptor antagonism by mirtazapine and its modifying effects on receptor signalling
(North-West University, 2004)
Mirtazapine is an atypical antidepressant employed clinically for the treatment of major depression. As a multipotent antagonist it acts at α2a-adrenergic receptors (α2a -ARs). serotonin type-2A receptors (5-HT2a-Rs) and ...
Genetic polymorphism in dextromethorphan metabolism by CYP2D6 and CYP3A4 enzyme isoforms
(North-West University, 2003)
Most administered drugs are metabolised in the liver by Phase I enzymes and more
importantly by the cytochrome P450 (CYP) system. The extent of first-pass metabolism is important in determining whether the drug will have ...
The role of myo-inositol in G-protein coupled receptor-mediated sub-cellular transduction mechanisms in neuronal cell lines
(North-West University, 2003)
myo-lnositol (ml), a simple polyol isomer of glucose, is an important osmolyte in the brain and a precursor of the phosphatidyl inositol metabolic pathway. It is known to facilitate various cellular events such as membrane ...
Investigating a novel antioxidant approach to the treatment of tardive dyskinesia
(North-West University, 2007)
Extrapyramidal side effects are the most frequently experienced side effects associated with neuroleptic drug use, while tardive dyskinesia (TD) remains one of the most debilitating of these side-effects, TD is a serious ...
Effects of early-life administration of methamphetamine on the depressive-like behaviour later in life in stress-sensitive and control rats
(2013)
Methamphetamine (MA) is a well-known, easily accessible and powerful psychostimulant, and its abuse has become a global problem. MA abuse affects millions of people worldwide and places an enormous burden on public healthcare ...
The effect of early–life exposure of rats to venlafaxine on behaviour and neurological markers of antidepressant action in adulthood
(2014)
Major depression is a serious mood disorder affecting more than 120 million people worldwide, irrespective of their race or socio-economic status. This psychiatric disorder is predicted to become the second leading cause ...
The long-term effects of fluoxetine on stress-related behaviour and acute monoaminergic stress response in stress sensitive rats
(2014)
Fluoxetine and escitalopram are the only antidepressants approved by the Food and Drug Administration of the United States of America (FDA) for treatment of major depression in children and adolescents. Both drugs are ...
An analysis of antidepressant noncompliance in the private health sector of South Africa
(2014)
The main aim of the thesis was to measure antidepressant (AD) non-compliance, to determine which factors are closely associated with AD non-compliance and the consequences of prolonged AD non-compliance in the private ...