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The influence of polycyclic amines on calcium homeostasis of neuronal cells
(North-West University, 2005)
Ineffective regulation of calcium homeostasis within the central nervous system has been
implicated as one of the main factors in the pathology underlying neurodegeneration.
Calcium influx is mainly gated through voltage ...
Isolation and characterisation of antimicrobial compounds from Antizoma angustifolia
(North-West University, 2004)
Infectious diseases are responsible for more than 17 million deaths per year worldwide, most of which are associated with bacterial infections. The increase in antibiotic resistance is thought to be a contributing factor ...
Biological activity profiles of selected polycyclic cage amines
(North-West University, 2004)
Parkinson's disease (PD) is a severe and debilitating age-related neurodegenerative
disease, with symptoms of resting tremor, akinesia and rigidity. The symptoms of PD
are due to the selective loss of dopaminergic neurons ...
Evaluation of N,N'-disubstituted 1,3-Diaminopropan-2-ols for anti-HIV activity
(North-West University, 2004)
The acquired immunodeficiency syndrome (AIDS) pandemic continuous to be a medical, social and economic challenge of staggering proportions. The human immunodeficiency virus (HIV) has been identified as the etiologic agent ...
Polycyclic indole derivatives as novel structures for neuroprotection
(North-West University, 2006)
The lethal triplet of metabolic compromise, excitotoxicity and oxidative stress causes
neuronal cell death that is both necrotic and apoptotic in nature. Aspects of each of these mechanisms are believed to play a role in ...
NOS inhibition of novel fluorescent polycyclic ligands
(North-West University, 2007)
In recent years polycyclic compounds have been shown to exhibit pharmacological profiles of importance in the symptomatic and proposed curative treatment of neurodegenerative diseases (e.g. Parkinson's and Alzheimer's ...
Antioxidant properties of 4-hydroxyquinolines
(North-West University, 2006)
Oxygen, although vital for human survival, is the main source of reactive oxygen species,
which can cause damage to essential biomolecules. Production of reactive oxygen
species is linked to normal cellular processes; ...
Antihistamines as neuroprotective agents
(North-West University, 2004)
Biomolecules are continuously exposed to potentially harmful oxidative stress as a consequence of free radical formation. Increased free radical generation has been associated with aging as well as neurodegenerative ...
Antimalarial compounds from Crinum Bulbispermum
(North-West University, 2004)
Malaria is caused by protozoan parasites of the genus Plasmodium, of which Plasmodium falciparum is the most widespread and dangerous. Around 800 000 children under the age of five die from malaria every year. An increase ...
Triquinylamines as regulators of calcium homeostasis of neuronal cells
(North-West University, 2007)
Neurodegenerative diseases include common and debilitating disorders such as
Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) and post-stroke neurodegeneration. Among these disorders, PD and ...