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Regional neurochemical characterization of the flinders sensitive line rat with regard to gaba and cholinergic signalling pathways
(North-West University, 2008)
Despite their acknowledged efficacy, currently available antidepressants still demonstrate undesirable side effects, shortfalls in effectiveness and a delayed onset of action. All these agents act via monoaminergic mechanisms, ...
Investigating the role of AMPAkines in an animal model of post-traumatic stress disorder (PTSD)
(North-West University, 2008)
Post-traumatic stress disorder (PTSD) is a severe anxiety disorder affecting cognitive function. 1 in 4 individuals exposed to a life-threatening event may develop PTSD, which is characterised by symptoms of hyperarousal, ...
A bio-behavioural investigation into the role of the cholinergic system in stress
(North-West University, 2006)
Posttraumatic stress disorder (PTSD) is an anxiety disorder that may follow exposure to
severe emotional trauma and presents with various symptoms of anxiety, hyperarousal and cognitive anomalies. Interestingly, only ...
Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats
(North-West University, 2007)
Schizophrenia affects approximately 1% of the population. Despite marked improvement in drug treatment, 20% of patients remain treatment resistant while motor side effects hamper compliance and outcome. A better understanding ...