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The modulating effect of myo-inositol and other antidepressants on the mRNA levels and protein expression of selected subcellular enzymes
(North-West University, 2005)
Myo-lnositol (mIns), a natural component of the human diet and essential precursor of
several signalling pathways, including that of G protein-coupled receptors, has also been
shown to be effective in the treatment of ...
The modulatory effects of sildenafil and the cholinergic system on antidepressant action in a rat model of depression
(North-West University, 2006)
Sildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, is registered for the treatment of male erectile dysfunction (Viagra®) and pulmonary hypertension (Revatio®) in the United States. PDE5 is found in the ...
The modulating effect of sildenafil on cell viability and on the function of selected pharmacological receptors in cell cultures
(North-West University, 2004)
Since sildenafil's (Viagra®), a phospodiesterase type 5 (PDE5) inhibitor, approval for the treatment of male erectile dysfunction (MED) in the United States early 1998, 274 adverse event reports were filed by the Food and ...
Investigating the role of the NO-cGMP pathway in an animal model of posttraumatic stress disorder (PTSD)
(North-West University, 2004)
Posttraumatic stress disorder (PTSD) is a severe anxiety disorder characterised by
hypothalamic-pituitary-adrenal (HPA)-axis abnormalities, hyperarousal, anxiety,
flashbacks of trauma memories and avoidance. Increasing ...