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Effects of early-life administration of methamphetamine on the depressive-like behaviour later in life in stress-sensitive and control rats
(2013)
Methamphetamine (MA) is a well-known, easily accessible and powerful psychostimulant, and its abuse has become a global problem. MA abuse affects millions of people worldwide and places an enormous burden on public healthcare ...
The effect of early–life exposure of rats to venlafaxine on behaviour and neurological markers of antidepressant action in adulthood
(2014)
Major depression is a serious mood disorder affecting more than 120 million people worldwide, irrespective of their race or socio-economic status. This psychiatric disorder is predicted to become the second leading cause ...
The long-term effects of fluoxetine on stress-related behaviour and acute monoaminergic stress response in stress sensitive rats
(2014)
Fluoxetine and escitalopram are the only antidepressants approved by the Food and Drug Administration of the United States of America (FDA) for treatment of major depression in children and adolescents. Both drugs are ...
An analysis of antidepressant noncompliance in the private health sector of South Africa
(2014)
The main aim of the thesis was to measure antidepressant (AD) non-compliance, to determine which factors are closely associated with AD non-compliance and the consequences of prolonged AD non-compliance in the private ...
Structure-activity relationship of methylene blue and its analogues as lead compounds for novel antidepressant development
(North-West University, 2010)
Antidepressants target serotonergic and/or catecholaminergic responses in an attempt at treating depression yet are at best 65% effective. New antidepressants, as well as new targets for antidepressant action, are thus ...
The long-term effects of methamphetamine on depressive-like behaviour and neuroplasticity in stress-sensitive rats
(2014)
Methamphetamine (METH) abuse has become a fast growing drug problem that has developed into a global epidemic. In fact, METH is one of the most commonly abused substances with an estimated 35 million abusers worldwide and ...
Bio-behavioural effects of novel glutamate active compounds in a rodent model of depression
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Major depressive disorder is a universal neuropsychiatric disorder affecting individuals on a global scale. It causes major disability independent of age, gender, ethnicity, sociological or economic status with an increasing ...
A metagenomic microbiome investigation in the deer mouse : a translational approach to obsessive-compulsive disorder
(North-West University (South-Africa), 2019)
Obsessive-compulsive disorder (OCD)1 is characterized by persistent, intrusive and often anxiety-provoking thoughts, i.e. obsessions and/or ritualistic behaviors (compulsions) that are expressed in an attempt to reduce the ...
Persistent behavioural phenotypes in the deer mouse and its response to serotonergic and dopaminergic intervention
(North-West University (South-Africa), 2019)
Obsessive compulsive disorder (OCD)1 is a debilitating psychiatric disorder that presents with intrusive thoughts (obsessions) and repetitive ritualistic behaviour (compulsions) as main symptoms. Selective reuptake inhibitors ...
Bio-behavioural evaluation of efavirenz and Δ9-tetrahydrocannabinol alone and in combination in rats with respect to psychosis and anxiety
(North-West University (South-Africa), 2019)
The highly active antiretroviral therapy, efavirenz (EFV), has been noted to occur as a constituent of a potent new designer drug cocktail called “Nyaope” or “Whoonga”, which is reported to have mind-altering and addictive-like ...