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Percutaneous absorption of cyclizine and its alkyl analogues
(North-West University, 2003)
Percutaneous delivery of drugs promises many advantages over oral or intravenous
administration, such as a better control of blood levels, a reduced incidence of systemic
toxicity, an absence of hepatic first-pass ...
Skin delivery of selected hydrophilic drugs used in the treatment of skin diseases associated with HIV/AIDS by using elastic liposomes
(North-West University, 2003)
Due to the immuncompromised status of AIDS patients, secondary infections and malignancies are common. Conditions secondary to AIDS for which patients require treatment include Karposi's sarcoma (treated with methotrexate), ...
Transdermal penetration of acyclovir in the presence and absence of terpenes
(North-West University, 2003)
Acyclovir is an antiviral drug used in the treatment and prevention of herpes simplex and varicella-zoster viral infections. The major problem in the transdermal delivery of acyclovir is the permeation in sufficient amounts ...
A retrospective analysis of the usage patterns of antiretroviral drugs : a pharmacoeconomic approach
(North-West University, 2008)
More people living with HIV/AIDS reside in South Africa than any other country in the world, and the nation faces colossal challenges in broadening its response to the now-mature and widespread HIV epidemic (WHO, 2005:1). ...
Pheroid technology for the topical delivery of insulin growth factor 1 (IGF-1), keratinocyte growth factor (KGF) and vascular endothelial growth factor (VEGF)
(North-West University, 2009)
The biotechnological era is here and many peptides and proteins are being used as part of
drug therapy. They are, however, not very stable and do not have the physicochemical
properties that allow for oral or topical ...
Synthesis and transdermal permeation of lamivudine derivatives
(North-West University, 2009)
The skin is the organ of the body that comes in contact with the outer environment. This means
that it has certain functions like protecting the body from excessive water loss and inhibiting the
entry of potentially ...
A comparative study between two lamellar gel phase systems and Emzaloids as delivery vehicles for the transdermal delivery of 5-fluorouracil and idoxuridine
(North-West University, 2004)
The distinctive architecture of the stratum corneum with its unique nature of an
interstitial lipoidal environment plays the major role in regulating the barrier function of the skin. The major problem with the transdermal ...
Formulation, in vitro release and transdermal diffusion of salicylic acid and topical niacinamide
(North-West University, 2009)
Acne affects as many as 80% of young adults and adolescents all over the world. This detrimental condition can be classified into four stages: (a) open comedo (blackhead), (b) closed comedo (whitehead), (c) papule and (d) ...
Formulation, in vitro release and transdermal diffusion of vitamin B3 for treatment of acne
(North-West University, 2009)
Acne is an extremely common condition, affecting almost 80% of adolescents and young adults. It is an inflammatory disease, characterised by comedones, papules, pustules and sometimes cysts. Factors causing acne include ...
Formulation, in-vitro release and transdermal diffusion of alpha-lipoic acid
(North-West University, 2009)
Acne is a common disease characterised by follicular hyperkeratinisation, bacterial hipercolonisation as well as immune reactions and inflammation. In acne, reactive oxygen species (ROS) may be released from the damaged ...