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The effect of grapefruit juice, a P-glycoprotein inhibitor, on organic acid and conjugates urinary profile in healthy human subjects
(North-West University, 2004)
P-glycoprotein (p-gp), a member of the superfamily ATP-binding cassette (ABC) is
known to be present in the absorptive enterocytes of the gastro-intestinal tract and
many other tissues in the body where it acts mainly ...
Investigating a pharmacological agent against tobacco smoke addiction using the rat as animal model
(North-West University, 2004)
It is widely accepted that the majority of people who smoke tobacco do so to experience the psychopharmacological effects of the nicotine present in the smoke. Drugs of abuse activate the brain area called the nucleus ...
The presence of ?-m-Hydroxyphenylhydracrylic acid in the urine of patients with ADHD and other neurodegenerative metabolic disorders
(North-West University, 2004)
β-m-Hydroxyphenylhydracrylic acid (BHHA) is an aromatic organic acid frequently detected in the urine of patients. The diagnostic value of this acid is as yet unknown. Previous reports indicated that BHHA may be of bacterial ...
Inhibition of monoamine oxidase B by substituted benzimidazole analogues
(North-West University, 2006)
Both monoamine oxidase A and B (MAO-A and B) play an important role in the metabolism of monoamine neurotransmitters in the central nervous system (CNS) and are therefore of considerable pharmacological interest for the ...
The effects of a tyrosine hydroxylase activator on the monoamine metabolism in rabbits exposed to tobacco smoke
(North-West University, 2006)
Nicotine is the most commonly used drug in the world today, with over 1.1 billion users worldwide, while smoking remains the single largest preventable cause of disease and premature death. Being the prime cause of cancer ...
The effect of exogenous coenzyme Q10 on its distribution and its role as protective agent against DNA damage
(North-West University, 2003)
Coenzyme Q10 (Q10) acts as an important in vivo anti-oxidant and has been widely advocated to be a beneficial dietary adjuvant because elevated concentrations of Q10 should effect a higher energy production and anti-oxidant ...
Inhibition of monoamine oxidase B by substituted coumarin derivatives
(North-West University, 2008)
Interest in the selective inhibition of monoamine oxidase B (MAO-B) has increased in the last years due to their therapeutic potential in age related neurodegenerative diseases such as Alzheimer's disease and Parkinson's ...
The preparation and evaluation of xanthinyl analogues as inhibitors of monoamine oxidase B
(North-West University, 2006)
Monoamine oxidase B (MAO-B) is a drug target for the treatment of neurodegenerative diseases such as Parkinson's disease. For example, the mechanism-based inactivator of MAO-B,
(R)-deprenyl, is frequently used in combination ...
The synthesis and evaluation of 8–benzyloxycaffeine analogues as inhibitors of monoamine oxidase B
(North-West University, 2009)
Monoamine oxidase, especially monoamine oxidase 8 (MAO-B), plays a major role in the therapy of Parkinson's disease (PO). MAO-8 is the main enzyme responsible for the catabolism of dopamine in the substantia nigra of the ...
The monoamine oxidase B substrate properties of selected pyrrolinyl analogues
(North-West University, 2008)
The parkinsonian inducing agent, 1-rnethyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP), is a cyclic tertiary allylamine that is oxidized by monoamine oxidase B
(MAO-B) at the ring a-carbon to yield the 1-rnethyl-4-pheny ...