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Inhibition of monoamine oxidase by selected 8–[(phenylsulfanyl)methyl]caffeine derivatives
(North-West University, 2012)
Purpose: Monoamine oxidase (MAO) consists of two isoforms, namely MAO-A and MAO-B. Both these isoforms are involved in the oxidation of dopamine. In Parkinson’s disease (PD) therapy, the inhibition of the oxidation of ...
The synthesis and evaluation of phenoxymethylcaffeine analogues as inhibitors of monoamine oxidase
(North-West University, 2010)
Purpose: Monoamine oxidase (MAO) plays a key role in the treatment of Parkinson's disease (PD), since it is the major enzyme responsible for the catabolism of dopamine in the substantia nigra of the brain. Inhibition of ...