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Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration
(North-West University, 2012)
Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events ...
Fluorescent polycyclic ligands : strategies towards the synthesis and evaluation of fluorescently labelled receptor and enzyme ligands
(North-West University, 2012)
Neurodegenerative disorders, including Alzheimer's and Parkinson's disease, and the
development of neuroprotective agents have received significant research attention in recent years. Development of novel imaging techniques ...