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Polycyclic indole derivatives as novel structures for neuroprotection
(North-West University, 2006)
The lethal triplet of metabolic compromise, excitotoxicity and oxidative stress causes
neuronal cell death that is both necrotic and apoptotic in nature. Aspects of each of these mechanisms are believed to play a role in ...
Antioxidant properties of 4-hydroxyquinolines
(North-West University, 2006)
Oxygen, although vital for human survival, is the main source of reactive oxygen species,
which can cause damage to essential biomolecules. Production of reactive oxygen
species is linked to normal cellular processes; ...
The preparation and evaluation of xanthinyl analogues as inhibitors of monoamine oxidase B
(North-West University, 2006)
Monoamine oxidase B (MAO-B) is a drug target for the treatment of neurodegenerative diseases such as Parkinson's disease. For example, the mechanism-based inactivator of MAO-B,
(R)-deprenyl, is frequently used in combination ...