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Amorphism and polymorphism of azithromycin
(North-West University, 2012)
Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ...
The development of paracetamol and dapsone amorphous solid dispersions
(North-West University (South-Africa), 2021)
The development of APIs was focused on the crystalline form over the years, but as the poor
solubility of new drugs increased, the focus turned to developing the amorphous form of the
drug. Dapsone (DAP) is no exception, ...
The development of efavirenz and praziquantel amorphous solid dispersions
(North-West University (South-Africa), 2019)
Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ...
The development of sulfadoxine and nevirapine pharmaceutical amorphous solid dispersions
(North-West University (South-Africa), 2019)
Solid oral dosage forms are the most convenient and prevalent dosage form in the pharmaceutical industry although an estimated 90% of drugs currently in development can be classified as poorly soluble. These drugs will ...
Rifampicin raw materials complexities and approaches to address solubility and in vitro permeability
(North-West University (South-Africa), 2021)
Tuberculosis is classified as a global emergency because it is taking lives at an alarming rate and developing countries with insufficient health care systems are primarily affected. Fixed dose combination drugs (FDCs) ...