Search
Now showing items 1-5 of 5
Amorphism and polymorphism of azithromycin
(North-West University, 2012)
Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ...
The physico–chemical properties of spiramycin and clarithromycin
(2012)
In most cases, organic materials exist in the solid phase as polymorphs, solvatomorphs or amorphous forms. Physico-chemical properties in the solid-state are all affected primarily in terms of dissolution, solubility, ...
Stability of amorphous azithromycin in a tablet formulation
(2014)
It is a well-known fact that drugs can exist in different solid-state forms. These solid-state forms can be either crystalline or amorphous. Furthermore, significant differences are identified between the different solid-state ...
The physico-chemical properties and recrystallisation kinetics of selected amorphous active ingredients
(North-West University (South Africa) , Potchefstroom Campus, 2015)
During the last two to three decades the application of amorphous solid-state forms within the pharmaceutical industry gained much interest. The rationale for this heightened interest is the increased aqueous solubility, ...
Roxithromycin : a solubility and stability study
(North-West University, 2011)
Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds to the 50S subunit of ...