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The modulating effect of myo-inositol and other antidepressants on the mRNA levels and protein expression of selected subcellular enzymes
(North-West University, 2005)
Myo-lnositol (mIns), a natural component of the human diet and essential precursor of
several signalling pathways, including that of G protein-coupled receptors, has also been
shown to be effective in the treatment of ...
Investigating a pharmacological agent against tobacco smoke addiction using the rat as animal model
(North-West University, 2004)
It is widely accepted that the majority of people who smoke tobacco do so to experience the psychopharmacological effects of the nicotine present in the smoke. Drugs of abuse activate the brain area called the nucleus ...
Characterisation of the ?2A-adrenoceptor antagonism by mirtazapine and its modifying effects on receptor signalling
(North-West University, 2004)
Mirtazapine is an atypical antidepressant employed clinically for the treatment of major depression. As a multipotent antagonist it acts at α2a-adrenergic receptors (α2a -ARs). serotonin type-2A receptors (5-HT2a-Rs) and ...
Genetic polymorphism in dextromethorphan metabolism by CYP2D6 and CYP3A4 enzyme isoforms
(North-West University, 2003)
Most administered drugs are metabolised in the liver by Phase I enzymes and more
importantly by the cytochrome P450 (CYP) system. The extent of first-pass metabolism is important in determining whether the drug will have ...
The role of myo-inositol in G-protein coupled receptor-mediated sub-cellular transduction mechanisms in neuronal cell lines
(North-West University, 2003)
myo-lnositol (ml), a simple polyol isomer of glucose, is an important osmolyte in the brain and a precursor of the phosphatidyl inositol metabolic pathway. It is known to facilitate various cellular events such as membrane ...
Investigating a novel antioxidant approach to the treatment of tardive dyskinesia
(North-West University, 2007)
Extrapyramidal side effects are the most frequently experienced side effects associated with neuroleptic drug use, while tardive dyskinesia (TD) remains one of the most debilitating of these side-effects, TD is a serious ...
The inhibition of phosphodiesterase type 5 as a novel target for antidepressant action
(North-West University, 2009)
Major depression is one of the most debilitating diseases of our time, while current antidepressant treatments remain deficient in several ways. The nitric oxide (NO) / cyclic guanosine monophosphate (cGMP) / cGMP-dependent ...
The modulating effect of myo-inositol and prototypical antidepressants on markers of cellular resilience in cultured human neuroblastoma cells
(North-West University, 2006)
Although several antidepressants are available for the treatment of depression, certain limitations are common, including drug resistance and significant side effects. Recently, several studies indicated the possibility ...
The role of the NO-cGMP pathway as a putative target in antidepressant action
(North-West University, 2004)
Depressive disorders are among the most frequent psychiatric diseases in the Western world with prevalence between 9% and 18%. Poor compliance and inappropriate antidepressant discontinuation invokes long-term morbidity, ...
Regional neurochemical characterization of the flinders sensitive line rat with regard to gaba and cholinergic signalling pathways
(North-West University, 2008)
Despite their acknowledged efficacy, currently available antidepressants still demonstrate undesirable side effects, shortfalls in effectiveness and a delayed onset of action. All these agents act via monoaminergic mechanisms, ...