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The long-term effects of fluoxetine on stress-related behaviour and acute monoaminergic stress response in stress sensitive rats
(2014)
Fluoxetine and escitalopram are the only antidepressants approved by the Food and Drug Administration of the United States of America (FDA) for treatment of major depression in children and adolescents. Both drugs are ...
Regional neurochemical characterization of the flinders sensitive line rat with regard to gaba and cholinergic signalling pathways
(North-West University, 2008)
Despite their acknowledged efficacy, currently available antidepressants still demonstrate undesirable side effects, shortfalls in effectiveness and a delayed onset of action. All these agents act via monoaminergic mechanisms, ...
Bio-behavioural effects of novel glutamate active compounds in a rodent model of depression
(North-West University (South Africa) , Potchefstroom Campus, 2015)
Major depressive disorder is a universal neuropsychiatric disorder affecting individuals on a global scale. It causes major disability independent of age, gender, ethnicity, sociological or economic status with an increasing ...
Investigating the role of AMPAkines in an animal model of post-traumatic stress disorder (PTSD)
(North-West University, 2008)
Post-traumatic stress disorder (PTSD) is a severe anxiety disorder affecting cognitive function. 1 in 4 individuals exposed to a life-threatening event may develop PTSD, which is characterised by symptoms of hyperarousal, ...
A bio-behavioural investigation into the role of the cholinergic system in stress
(North-West University, 2006)
Posttraumatic stress disorder (PTSD) is an anxiety disorder that may follow exposure to
severe emotional trauma and presents with various symptoms of anxiety, hyperarousal and cognitive anomalies. Interestingly, only ...
The role of monoamines in post traumatic stress disorder (PTSD) using a time dependent sensitization animal model
(North-West University, 2004)
Posttraumatic stress disorder (PTSD) is an anxiety disorder that may result from an exposure to a severely traumatic life-event. It is characterised by a delayed onset of psychological and physical symptoms including ...
Stereotypical behaviour in the deer mouse (Peromyscus Maniculatus bairdii) : a pharmacological investigation of the frontal–cortico–striatal serotonergic system
(North-West University, 2011)
Obsessive–compulsive disorder (OCD) is a psychiatric condition that is characterized by two main symptom cohorts, namely recurrent inappropriate thoughts (obsessions) and seemingly purposeless repetitive motor actions ...
Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats
(North-West University, 2007)
Schizophrenia affects approximately 1% of the population. Despite marked improvement in drug treatment, 20% of patients remain treatment resistant while motor side effects hamper compliance and outcome. A better understanding ...