Browsing Health Sciences by Subject "Reversible inhibition"
Now showing items 1-4 of 4
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The antidepressant properties of selected methylene blue analogues
(2014)The shortcomings of current antidepressant agents prompts the design of novel multimodal antidepressants and the identification of new antidepressant targets, especially those located at sub-cellular level. Such ... -
The design, synthesis and evaluation of aminocaffeine derivatives as inhibitors of monoamine oxidase B
(North-West University, 2011)Monoamine oxidase (MAO) is responsible for dopamine catabolism in the brain and therefore is especially important in the treatment of Parkinson's disease (PD). MAO–B inhibition provides symptomatic relief by indirectly ... -
Monoamine oxidase inhibition by novel quinolinones
(2014)Parkinson’s disease (PD) is an age-related neurodegenerative disorder. The degeneration of the neurons of the substantia nigra in the midbrain leads to the loss of dopamine from the striatum, which is responsible for the ... -
Synthesis and evaluation of 3,4-Dihydro-3-methyl-2(1H)-quinazolinone derivatives as monoamine oxidase inhibitors
(North-West University, Potchefstroom Campus, 2018)Parkinson’s disease (PD) is an age related neurodegenerative disorder. Loss of dopamine from the striatum is responsible for the motor symptoms of PD. This loss of dopamine is due to degeneration of the neurons of the ...