Browsing Health Sciences by Subject "Hippocampus"
Now showing items 1-8 of 8
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Behavioral, neuroendocrine and neurochemical studies on agomelatine in social isolation reared rats
(North-West University (South Africa) , Potchefstroom Campus, 2015)1. Introduction. There is currently a large body of evidence suggesting that stressful early life experiences, such as maternal separation and social isolation, may play a role in the development of major depressive disorder ... -
Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
A bio-behavioural investigation into the role of the cholinergic system in stress
(North-West University, 2006)Posttraumatic stress disorder (PTSD) is an anxiety disorder that may follow exposure to severe emotional trauma and presents with various symptoms of anxiety, hyperarousal and cognitive anomalies. Interestingly, only ... -
Investigating the role of AMPAkines in an animal model of post-traumatic stress disorder (PTSD)
(North-West University, 2008)Post-traumatic stress disorder (PTSD) is a severe anxiety disorder affecting cognitive function. 1 in 4 individuals exposed to a life-threatening event may develop PTSD, which is characterised by symptoms of hyperarousal, ... -
An investigation into the effects of Sceletium tortuosum in a methamphetamine addiction model in Sprague Dawley rats
(North-West University (South-Africa), 2021)Background: Methamphetamine (MA), globally known as “crystal meth”, is a highly addictive psychostimulant, which can be easily synthesized by using over the counter medicine and common household items. It induces intense ... -
A pharmacokinetic-pharmacodynamic relationship study between GABA-ergic drugs and anxiety levels in an animal model of PTSD
(North-West University, 2005)Posttraumatic stress disorder (PTSD) is classified as an anxiety disorder and the characteristic symptoms (re-experiencing, avoidance as well as numbing of general responsiveness and hyperarousal) of this disorder develop ... -
Regional neurochemical characterization of the flinders sensitive line rat with regard to gaba and cholinergic signalling pathways
(North-West University, 2008)Despite their acknowledged efficacy, currently available antidepressants still demonstrate undesirable side effects, shortfalls in effectiveness and a delayed onset of action. All these agents act via monoaminergic mechanisms, ... -
The role of monoamines in post traumatic stress disorder (PTSD) using a time dependent sensitization animal model
(North-West University, 2004)Posttraumatic stress disorder (PTSD) is an anxiety disorder that may result from an exposure to a severely traumatic life-event. It is characterised by a delayed onset of psychological and physical symptoms including ...