Browsing Health Sciences by Subject "HPLC"
Now showing items 1-7 of 7
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The antioxidant properties of the methanol extract of Cotyledon orbiculata L. var orbiculata (Haw.) DC. Leaves
(North-West University, [2012])South Africa is a country of great diversity. Different climate zones and a host of different habitats make South Africa the perfect platform for rich floral diversity. This floral diversity lends itself to the study of ... -
The detection and quantification of biomolecules in biological sample matrices
(North-West University (South-Africa), 2019)In the bodies of living humans and animals, endogenous biomolecules, and in particular the chemical messengers, play an essential role in the maintenance and functionality of physiological processes (Daintith, 2008; Gault ... -
Development of a stability indicating HPLC method for the Pheroid™ delivery system
(North-West University, 2010)Stability plays an important role in the development of a new drug product. High Performance Liquid Chromatography (HPLC) is considered a stability indicating method of analysis. It is widely used in the pharmaceutical ... -
The development of efavirenz and praziquantel amorphous solid dispersions
(North-West University (South-Africa), 2019)Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ... -
The development of ritonavir and pyrimethamine amorphous solid dispersions
(North-West University (South-Africa), 2021)Poorly soluble drugs are a major problem in the pharmaceutical industry. Not only does it lead to formulation difficulties, but it also leads to poor absorption and poor bioavailability of drugs. Ritonavir (RTV) is a ... -
Genetic polymorphism in dextromethorphan metabolism by CYP2D6 and CYP3A4 enzyme isoforms
(North-West University, 2003)Most administered drugs are metabolised in the liver by Phase I enzymes and more importantly by the cytochrome P450 (CYP) system. The extent of first-pass metabolism is important in determining whether the drug will have ... -
The pharmacokinetic interaction between cyclosporine and methoxsalen
(North-West University, 2003)Cyclosporine forms the cornerstone of therapy to prevent rejection after organ transplantation. However, the clinical use of the drug is compromised by a narrow therapeutic window and a wide inter- and intra-individual ...