Browsing Health Sciences by Subject "Flinders Sensitive Line rat"
Now showing items 1-3 of 3
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Development and validation of an animal model of treatment-resistant depression with psychotic features
(North-West University (South-Africa), 2021)Major depression (MD) affects up to 17% of the global population. While effective treatments for MD exist, an underlying interaction between genetic propensity and chronic and/or early life adversity may render these drugs ... -
Early-life exposure to fluoxetine and/or exercise on bio-behavioural markers of depression in early adulthood in stress sensitive rats
(North-West University (South Africa) , Potchefstroom Campus, 2015)Juvenile depression is a major concern worldwide, with only the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and escitalopram approved for treatment. The effects of early-life exposure to SSRIs on neurodevelopment ... -
Effects of early-life administration of methamphetamine on the depressive-like behaviour later in life in stress-sensitive and control rats
(2013)Methamphetamine (MA) is a well-known, easily accessible and powerful psychostimulant, and its abuse has become a global problem. MA abuse affects millions of people worldwide and places an enormous burden on public healthcare ...