Browsing Health Sciences by Author "Terre'Blanche, G."
Now showing items 1-14 of 14
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Affinity of dihydropyrimidone analogues for adenosine A1 and A2A receptors
Katsidzira, Runako Masline (2014)Parkinson’s disease (PD) is a neurodegenerative disorder that is characterised by a reduction of dopamine concentration in the striatum due to degeneration of dopaminergic neurons in the substantia nigra. Currently, first ... -
The design, synthesis and evaluation of aminocaffeine derivatives as inhibitors of monoamine oxidase B
Moraal, Christina Maria (North-West University, 2011)Monoamine oxidase (MAO) is responsible for dopamine catabolism in the brain and therefore is especially important in the treatment of Parkinson's disease (PD). MAO–B inhibition provides symptomatic relief by indirectly ... -
The effects of a tyrosine hydroxylase activator on the monoamine metabolism in rabbits exposed to tobacco smoke
Coetzee, Donovan (North-West University, 2006)Nicotine is the most commonly used drug in the world today, with over 1.1 billion users worldwide, while smoking remains the single largest preventable cause of disease and premature death. Being the prime cause of cancer ... -
The inhibitory effect of erucic acid on the polyunsaturated fatty acids in Sprague-Dawley rats
Louw, Aletta Petronella (North-West University, 2009)X-adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder characterized by the accumulation of saturated unbranched very long chain fatty acids (VLCFA), particularly hexacosanoic acid (C26:0) and tetracosanoic ... -
Investigating a pharmacological agent against tobacco smoke addiction using the rat as animal model
Nel, Linda (North-West University, 2004)It is widely accepted that the majority of people who smoke tobacco do so to experience the psychopharmacological effects of the nicotine present in the smoke. Drugs of abuse activate the brain area called the nucleus ... -
Investigating the potential neuroprotective effects of statins on DNA damage in mice striatum
Coetsee, Tjaart Nicolaas (North-West University, 2006)Parkinson's disease occurs after loss of the nigrostriatal neurons responsible for regulating normal motor function (Chase, et al., 1998). Oxidative damage to DNA is caused by endogenous cellular sources (Marnett, 2000) ... -
The metabolic profile of phenylbutyric acid and its antioxidant capacity in vervet monkeys
Van der Linde, Wilhelmina Johanna (North-West University, 2010)X–linked adrenoleukodystrophy (X–ALD) is the most common peroxisomal enzyme deficiency disorder, characterized by inborn mutations in the ABCD1 gene, an ATP–binding cassette (ABC) half–transporter. The ABCD1 gene encodes ... -
The monoamine oxidase B substrate properties of selected pyrrolinyl analogues
Pretorius, Anél (North-West University, 2008)The parkinsonian inducing agent, 1-rnethyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is a cyclic tertiary allylamine that is oxidized by monoamine oxidase B (MAO-B) at the ring a-carbon to yield the 1-rnethyl-4-pheny ... -
The presence of ?-m-Hydroxyphenylhydracrylic acid in the urine of patients with ADHD and other neurodegenerative metabolic disorders
Stoltz, Nadia (North-West University, 2004)β-m-Hydroxyphenylhydracrylic acid (BHHA) is an aromatic organic acid frequently detected in the urine of patients. The diagnostic value of this acid is as yet unknown. Previous reports indicated that BHHA may be of bacterial ... -
The role of fatty acids in drug resistant epilepsy
Krüger, Andra (North-West University, 2006)Refractory epilepsy is a complex disorder, affecting approximately 40% of epilepsy patients. To date, no medication has been found to be effective in the treatment of this disorder, except for the ketogenic diet and w-3 ... -
The role of p-glycoprotein and peptides in attention deficit disorder with hyperactivity (ADHD)
Van Zyl, Hester (North-West University, 2004)A characteristic peptide profile was detected in the urine of certain patients suffering from ADHD. The purpose of this study was to determine whether defective p-glycoprotein may be responsible for the occurrence of this ... -
Syntheses of 8–(phenoxymethyl)caffeine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of the adenosine A2A receptor
Harmse, Rozanne (North-West University, 2013)Background and rationale: Parkinson’s disease (PD) is a progressive, degenerative disorder of the central nervous system and is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The ... -
Syntheses of sulfanylphthalimide and xanthine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of adenosine receptors
Van der Walt, Mietha Magdalena (North-West University, 2013)Currently L-DOPA is the drug most commonly used for the treatment of Parkinson’s disease (PD). However, the long-term use of L-DOPA is associated with the development of motor fluctuations and dyskinesias. Treatment mainly ... -
The synthesis and evaluation of N-methyl-2-phenylmaleimide analogues as inhibitors of MAO-B
Manley-King, Clarina Ilara (North-West University, 2008)We have recently demonstrated that 1-methyl-3-phenylpyrrole analogues are moderately potent competitive inhibitors of the enzyme monoamine oxidase B (MAO-B). The most potent analogue was 1-methyl-(4-trifluoromethylphenyl) ...