Browsing Health Sciences by Author "Petzer, A."
Now showing items 1-17 of 17
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Affinity of dihydropyrimidone analogues for adenosine A1 and A2A receptors
Katsidzira, Runako Masline (2014)Parkinson’s disease (PD) is a neurodegenerative disorder that is characterised by a reduction of dopamine concentration in the striatum due to degeneration of dopaminergic neurons in the substantia nigra. Currently, first ... -
Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase
De Beer, Johannie (2015)Parkinson’s disease is a bradykinetic disorder that is the result of the death of dopaminergic neurons in the basal ganglia of the brain. This, in turn, leads to the depletion of dopamine in the striatum, which is responsible ... -
Evaluation of nitrocatechol bearing cyclic chalcones and related analogues as dual monoamine oxidase and catechol-O-methyltransferase inhibitors
De Beer, Andries Daniël (North-West University (South-Africa), 2020)Parkinson’s disease (PD) is one of the leading causes of disability in the world. A better understanding of the aetiology of this disorder will lead to better medications, and would improve the quality of life for millions ... -
Evaluation of selected dye compounds as inhibitors of enzymes, relevant to neurological disorders
Cloete, S.J. (North-West University (South-Africa), 2021)Neurological disorders such as Alzheimer’s disease, Parkinson’s disease and schizophrenia are disorders that affect a large part of the population, especially the elderly. The cause of these disorders is still not completely ... -
Evaluation of selected dye compounds as inhibitors of monoamine oxidase
De Beer, Franciska (North-West University (South-Africa), 2019)Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative diseases that significantly impact the quality of life of patients. The pathology of Parkinson’s disease is characterised by neuronal death of the ... -
In vitro and in silico antimicrobial evaluation of N- methyl-2-phenylmaleimides
Fourie, Carla-Christie (North-West University (South-Africa), 2023)Due to COVID-19, many other pandemics have been overlooked in the past few years. Antimicrobial resistance (AMR) is a pandemic that have killed more people than Human Immunodeficiency Virus (HIV) and malaria in 2019 and ... -
Method development and validation for the analysis of medicinal cannabis products, aimed at developing a safety profile for South Africa
Viviers, Hendrik Jacobus (North-West University (South-Africa), 2022)In the last few years, there has been an increase in the use of cannabis-based products for medicinal purposes. The preparation procedure, however, has not been standardised but is decided by the individual groups of ... -
Method development for extraction and HPLC analysis of kaempferol, chrysin and quercetin
Ludick, Nicolaas Johannes Jacobus (North-West University (South-Africa), 2020)Flavonoids (different phytochemical compounds found in plants acting as phytoalexins), have been found to have potent antioxidant effects. This has led into studies conducted on its effect on the body in reducing oxidative ... -
Methylene blue analogues : in vitro antimicrobial activity and in silico pharmacophore modelling
Thesnaar, L.C. (North-West University (South-Africa), 2021)Antibiotics have drastically reduced the morbidity and mortality associated with fatal infections and have made previously impossible procedures, e.g. heart surgery, possible by allowing infections to be prevented or ... -
Monoamine oxidase inhibition by indanone and benzoquinone analogues
Mostert, Samantha (North-West University (South Africa) , Potchefstroom Campus, 2015)Parkinson’s disease (PD) is a neurological disorder of which aging is the greatest risk factor. Over the next fifteen years, the number of persons affected by PD worldwide is expected to increase from 4.6 million to 9.3 ... -
Monoamine oxidase inhibition by novel quinolinones
Meiring, Letitia (2014)Parkinson’s disease (PD) is an age-related neurodegenerative disorder. The degeneration of the neurons of the substantia nigra in the midbrain leads to the loss of dopamine from the striatum, which is responsible for the ... -
Monoamine oxidase inhibitory activities of heterocyclic chalcones
Minders, Corné (2013)Parkinson’s disease is the second most common age-related neurodegenerative disease after Alzheimer’s disease. The characteristic pathological feature of Parkinson’s disease is the loss of neurons in the substantia nigra ... -
Syntheses of 8–(phenoxymethyl)caffeine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of the adenosine A2A receptor
Harmse, Rozanne (North-West University, 2013)Background and rationale: Parkinson’s disease (PD) is a progressive, degenerative disorder of the central nervous system and is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The ... -
Synthesis and biological evaluation of 6-substituted coumaranone derivatives and related compounds as monoamine oxidase inhibitors
Van Dyk, Adriaan Sarel (2014)Parkinson’s disease (PD) is an age related neurodegenerative disorder that presents with both motor and non-motor symptoms. The most common pathological characteristic of PD is the loss of the pigmented dopaminergic neurons ... -
Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase
Mpitimpiti, Annah Nyasha (2014)BACKGROUND AND RATIONALE Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder affecting the central nervous system, primarily, the substantia nigra. It is characterized by loss of dopaminergic ... -
Synthesis and evaluation of sesamol derivatives as inhibitors of monoamine oxidase
Engelbrecht, Idalet (2014)Parkinson’s disease is an age-related neurodegenerative disorder. The major symptoms of Parkinson’s disease are closely linked to the pathology of the disease. The main pathology of Parkinson’s disease consists of the ... -
Synthesis, characterisation and properties of fulvic acid, derived from a carbohydrate
Jordaan, Imelda Latitia (North-West University (South-Africa), 2019)Introduction: Human and animal health is constantly threatened by pathogenic microbes and the emergence of bacteria resistant to standard medicinal interventions has escalated the search for new and innovative pharmaceutical ...