Browsing Health Sciences by Author "Aucamp, M."
Now showing items 1-5 of 5
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Improvement of the pharmaceutical availability and membrane permeability of furosemide by formulation design
Van der Merwe, C.J. (North-West University (South-Africa), 2021)Furosemide is a well-known loop diuretic having weak acidic chemical properties. Furosemide belongs to the Biopharmaceutical Classification System (BCS) class IV because it has poor aqueous solubility and poor membrane ... -
The physico–chemical properties of spiramycin and clarithromycin
Van Eeden, Rodé (2012)In most cases, organic materials exist in the solid phase as polymorphs, solvatomorphs or amorphous forms. Physico-chemical properties in the solid-state are all affected primarily in terms of dissolution, solubility, ... -
Roxithromycin : a solubility and stability study
Van Niekerk, Elzet (North-West University, 2011)Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds to the 50S subunit of ... -
Stability of amorphous azithromycin in a tablet formulation
Obulapuram, Prasanna Kumar (2014)It is a well-known fact that drugs can exist in different solid-state forms. These solid-state forms can be either crystalline or amorphous. Furthermore, significant differences are identified between the different solid-state ... -
Stability of amorphous forms of roxithromycin when encapsulated in liposomes
Swart, Michelene (North-West University (South-Africa), 2019)Acne vulgaris is a common chronic inflammatory disease, which affects the pilosebaceous units in the dermal layer of the skin (Krautheim & Gollnick, 2004:398; Williams et al., 2012:361). Several factors are involved during ...