Browsing Health Sciences by Subject "Parkinson's disease"
Now showing items 1-10 of 13
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5-Hydroxy-1-tetralone analogues as dual A1/A2A receptor antagonists for the potential treatment of neurological conditions
(North-West University, 2018)Parkinson's disease (PD), a classic movement disorder, is the second most common neurological condition after Alzheimer's disease, with higher incidence and prevalence in advanced age — consequently, PD patients' quality ... -
5-Hydroxy-1-tetralone analogues as dual A1/A2A receptor antagonists for the potential treatment of neurological conditions
(North-West University (South Africa), Potchefstroom Campus, 2018)Parkinson’s disease (PD), a classic movement disorder, is the second most common neurological condition after Alzheimer’s disease, with higher incidence and prevalence in advanced age — consequently, PD patients’ quality ... -
Adenosine A1/A2A receptor antagonistic properties of selected 2-substituted benzoxazinone and quinazolinone derivatives
(North-West University (South Africa), Potchefstroom Campus, 2018)The A1 and A2A adenosine receptor antagonists are the subject of extensive research based on their aptitude for ameliorating Parkinson’s disease related cognitive deficits (A1 adenosine receptor subtype) and motor dysfunction ... -
Design and synthesis of dual acting carbamate inhibitors of acetylcholinesterase and monoamine oxidase
(North-West University (South Africa) , Potchefstroom Campus, 2017)Alzheimer’s disease (AD), the most common neurodegenerative disorder, affects about 10% of the population over the age of 65 years. The disease is typified by symptoms such as memory loss and impairment in abilities including ... -
Design, synthesis and evaluation of novel levodopa pro-drugs for the treatment of Parkinson's disease
(North-West University, 2018)Parkinson's disease is a slowly progressive neurodegenerative disorder of unknown cause that selectively affects the dopaminergic, extrapyramidal nigrostriatal pathway. Parkinson's disease is a mid- or late life disease, ... -
Design, synthesis and evaluation of quinazolinone analogues as monoamine oxidase inhibitors
(North-West University (South Africa), Potchefstroom Campus, 2018)Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, and it is estimated to affect approximately 1% of the population over the age of 65. PD is characterised by non-motor ... -
Discovery of catechol-O-methyltransferase inhibitors through virtual screening
(North-West University (South Africa) , Potchefstroom Campus, 2016)BACKGROUND AND RATIONALE: Parkinson’s disease (PD) is a progressive neurodegenerative disease that is caused by the death of dopaminergic neurons in the substantia nigra resulting in a loss of dopamine in the striatum. ... -
The monoamine oxidase inhibition properties of caffeine analogues containing saturated C–8 substituents
(North-West University, 2010)Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized pathologically by a marked loss of dopaminergic nigrostriatal neurons and clinically by disabling movement disorders. PD can be treated ... -
Prescribing patterns of medicines used in Parkinson's and other related diseases in the private health care sector of South Africa
(North-West University, 2010)Parkinson's disease is the most recurrent movement disorder and has a radical effect on the lives of people. This chronic neurological disorder is accompanied by a significant social and financial burden with a negative ... -
Synthesis and evaluation of cyclic chalcones as monoamine oxidase inhibitors
(North-West University (South Africa) , Potchefstroom Campus, 2016)Parkinson’s disease (PD) is the second most-prevalent age-related neurodegenerative disorder following Alzheimer’s disease. The manifestation of clinical PD begins after a loss of neurons from the substantia nigra pars ...