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Metallothionein involvement in mitochondrial function and disease : a metabolomics investigation
(North-West University, 2011)
One of the many recorded adaptive responses in respiratory chain complex I deficient cells is the over-expression of the small metal binding proteins, metallothioneins (MTs). The antioxidant
properties of MTs putatively ...
Characterising tuberculosis and treatment failure thereof using metabolomics
(North-West University, Potchefstroom Campus, 2017., 2017)
Tuberculosis (TB), a highly contagious bacterial disease caused by Mycobacterium
tuberculosis, is considered the leading cause of death globally from a single bacterial
pathogen. The latest reports indicate 10.4 million ...
A metabolomics investigation of tuberculous meningitis in infants and children
(North-West University (South Africa), 2016)
This thesis, titled: ‘A metabolomics investigation of Tuberculous Meningitis in infants and children’, deals with tuberculous meningitis (TBM), the most severe complication of tuberculosis (TB) and major pandemic of our ...
Metabolic variation in cultured cells treated with differentially functionalised gold nanoparticles (GNPs)
(North-West University (South Africa), Potchefstroom Campus, 2017)
Gold nanoparticles (GNPs) and differentially functionalised or ligand exchanged GNPs (Lig-GNPs) present promising advantages in a variety of fields. Surface functionalisation of GNPs with ligands is believed to improve the ...
Improving a biosignature for respiratory chain deficiencies in a South African cohort
(North-West University (South Africa) , Potchefstroom Campus, 2016)
Mitochondria are the cell’s main energy producing site, found in the cytoplasm of nearly all eukaryotic cells. These organelles generate cellular energy in the form of adenosine triphosphate (ATP), mostly by means of the ...
Standardisation and implementation of an optimised method for lipid profiling of microbial communities
(North-West University (South Africa), 2016)
Although the importance of phospholipid fatty acid (PLFA) analysis to characterise microbial
communities has been recognised over the years, the vast number of modifications to this traditional
method as well as discrepancies ...
Metabolomics of hypertension in South Africans : the SABPA Study
(North-West University (South Africa), 2015)
There has been growing concern in recent years about the alarmingly high prevalence and
severity of hypertension and other cardiovascular diseases in individuals from newly (or
recently) westernised countries such as ...
The altered fatty acylcarnitines, amino acids and organic acids detected in tuberculosis patient urine
(North-West University (South Africa), Potchefstroom Campus, 2018)
Mycobacterium tuberculosis is estimated to infect approximately one-third of the world’s
population, which can lead to an active, symptomatic disease called tuberculosis (TB), or to
asymptomatic states, often referred ...
Characterising the immunometabolic profile of HIV/TB co-infection
(North-West University (South Africa), 2022)
The synergy between the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb),
the causative agent of tuberculosis (TB) during co-infection of a host is well established. While this
synergy is driven ...
Automated processing of untargeted 1H-NMR metabolomics data of urine from treated TB patients
(North-West University (South Africa), 2022)
Metabolomics is becoming an increasingly popular field of study. An analytical platform commonly used for metabolomics studies is proton nuclear magnetic resonance (1H-NMR) spectroscopy. The main challenge of 1H-NMR is ...