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Formulation, characterisation and in vivo efficacy of dapsone and proguanil in trimethylated chitosan microparticles
Malaria is an infectious disease caused by various forms of the Plasmodium parasite. It is responsible for thousands of deaths yearly with 90 % of those deaths being in sub-Saharan Africa, thus making it a disease of global ...
Permeation of excised intestinal tissue by insulin released from Eudragit® L100/Trimethyl chitosan chloride microspheres
(North-West University, 2013)
The purpose of this research project was to develop and characterise matrix type microspheres prepared from Eudragit® L100, containing insulin as model peptide drug as well as an absorption enhancer, N-trimethyl chitosan ...
Hemocompatibility of N–trimethyl chitosan chloride nanoparticles
Research on nanoparticles for pharmaceutical applications has become increasingly popular in recent years. N-trimethyl chitosan chloride (TMC) is a cationic polymer that can enhance absorption across mucosal surfaces. It ...
Development of a mini-tablet-in-capsule dosage form for macromolecular drug delivery
(North-West University (South-Africa), 2020)
Oral delivery of protein and peptide drugs faces immense challenges, partially due to the inherent unfavourable characteristics of the molecules and partially due to the unfavourable gastrointestinal environment. These ...