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Investigation and characterisation of the genetic variation in the coding region of the glycine N-acyltransferase gene
(North-West University, 2015)
Thorough investigation of the glycine conjugation pathway has been neglected over the last 30 years. Environmental factors, nutrition, and the chronic use of medications are increasing the exposure of humans to benzoate ...
Phase I and II biotransformation in patients with chronic fatigue
(North-West University (South Africa), 2020)
This thesis, titled: ‘Phase I and II biotransformation in patients with chronic fatigue’, forms part of the research and development programme of the Centre for Human Metabolomics at the NWU. There is no consensus definition ...
The establishment of a model system in which variants of the medium-chain ligase (ACSM) and glycine N-acyltransferase (GLYAT) can be co-expressed and analysed
(North-West University (South Africa), 2022)
Even though glycine conjugation pathway discovery dates back to the 18th century, it is still an important detoxification pathway that is severely neglected in research. Xenobiotics are omnipresent in the environment (as ...
The identification of genetic variation in the acyl-CoA synthetase genes (ACSM2A and ACSM2B)
(North-West University (South Africa), Potchefstroom Campus, 2016)
Investigations into the role of the glycine conjugation pathway and specifically the functioning and significant importance of the mitochondrial medium-chain ligases have seriously been neglected over the last 30 years. ...