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dc.contributor.authorCampagne, Pascal
dc.contributor.authorVan den Berg, Johnnie
dc.contributor.authorSmouse, Peter E.
dc.contributor.authorPasquet, Rémy
dc.contributor.authorSilvain, Jean-Francois
dc.date.accessioned2017-05-10T09:38:24Z
dc.date.available2017-05-10T09:38:24Z
dc.date.issued2016
dc.identifier.citationCampagne, P. et al. 2016. Impact of violated high-dose refuge assumptions on evolution of Bt resistance. Evolutionary applications, ((4):596-607. [http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1752-4571/]en_US
dc.identifier.issn1752-4563
dc.identifier.issn1752-4571 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/21826
dc.identifier.urihttp://dx.doi.org/10.1111/eva.12355
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/eva.12355/full
dc.description.abstractTransgenic crops expressing Bacillus thuringiensis (Bt) toxins have been widely and successfully deployed for the control of target pests, while allowing a substantial reduction in insecticide use. The evolution of resistance (a heritable decrease in susceptibility to Bt toxins) can pose a threat to sustained control of target pests, but a high-dose refuge (HDR) management strategy has been key to delaying countervailing evolution of Bt resistance. The HDR strategy relies on the mating frequency between susceptible and resistant individuals, so either partial dominance of resistant alleles or nonrandom mating in the pest population itself could elevate the pace of resistance evolution. Using classic Wright-Fisher genetic models, we investigated the impact of deviations from standard refuge model assumptions on resistance evolution in the pest populations. We show that when Bt selection is strong, even deviations from random mating and/or strictly recessive resistance that are below the threshold of detection can yield dramatic increases in the pace of resistance evolution. Resistance evolution is hastened whenever the order of magnitude of model violations exceeds the initial frequency of resistant alleles. We also show that the existence of a fitness cost for resistant individuals on the refuge crop cannot easily overcome the effect of violated HDR assumptions. We propose a parametrically explicit framework that enables both comparison of various field situations and model inference. Using this model, we propose novel empiric estimators of the pace of resistance evolution (and time to loss of control), whose simple calculation relies on the observed change in resistance allele frequencyen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectFitness costen_US
dc.subjectHigh-doseen_US
dc.subjectIncomplete resistanceen_US
dc.subjectInsecticide resistanceen_US
dc.subjectNonrandom matingen_US
dc.subjectPartial dominanceen_US
dc.subjectRefuge strategyen_US
dc.titleImpact of violated high-dose refuge assumptions on evolution of Bt resistanceen_US
dc.typeArticleen_US
dc.contributor.researchID12319724 - Van den Berg, Johann


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